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Dajnoki, Z.* ; Kapitány, A.* ; Eyerich, K.* ; Eyerich, S. ; Törőcsik, D.* ; Szegedi, A.*

Topographical variations in the skin barrier and their role in disease pathogenesis.

J. Eur. Acad. Dermatol. Venereol., DOI: 10.1111/jdv.20463 (2024)
Verlagsversion DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
The skin barrier can be divided into at least four functional units: chemical, microbial, physical and immunological barriers. The chemical and microbial barriers have previously been shown to exhibit different characteristics in topographically distinct skin regions. There is increasing evidence that the physical and immunological barriers also show marked variability in different areas of the skin. Here, we review recent data on the topographical variations of skin barrier components, the contribution of these variations to the homeostatic function of the skin and their impact on the pathogenesis of specific immune-mediated skin diseases (such as atopic dermatitis and papulopustular rosacea). Recognition of these topographical barrier differences will improve our understanding of skin homeostasis and disease pathogenesis and provide a basis for body site-specific targeted therapies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Memory T-cells; Atopic-dermatitis; Staphylococcus-aureus; Microbiome; Inflammation; Rosacea; Surface; Keratinocytes; Colonization; Expression
ISSN (print) / ISBN 0926-9959
e-ISSN 1468-3083
Zeitschrift Journal of the European Academy of Dermatology and Venereology
Verlag Wiley
Verlagsort 111 River St, Hoboken 07030-5774, Nj Usa
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Allergy Research (IAF)
Förderungen HUN-REN Hungarian Research Network