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Zinzula, L.* ; Beck, F.* ; Camasta, M.* ; Bohn, S. ; Liu, C.* ; Morado, D.* ; Bracher, A.* ; Plitzko, J.M.* ; Baumeister, W.*

Cryo-EM structure of single-layered nucleoprotein-RNA complex from Marburg virus.

Nat. Commun. 15:10307 (2024)
Verlagsversion DOI PMC
Free journal
Creative Commons Lizenzvertrag
Marburg virus (MARV) causes lethal hemorrhagic fever in humans, posing a threat to global health. We determined by cryogenic electron microscopy (cryo-EM) the MARV helical ribonucleoprotein (RNP) complex structure in single-layered conformation, which differs from the previously reported structure of a double-layered helix. Our findings illuminate novel RNP interactions and expand knowledge on MARV genome packaging and nucleocapsid assembly, both processes representing attractive targets for the development of antiviral therapeutics against MARV disease.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Ebola-virus; Features
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Zeitschrift Nature Communications
Quellenangaben Band: 15, Heft: 1, Seiten: , Artikelnummer: 10307 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Förderungen Projekt DEAL