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Rodionov, R.N.* ; Jarzebska, N.* ; Koay, Y.C.* ; Li, M.* ; Kuhn, M.* ; Bornstein, S.R.* ; Martens-Lobenhoffer, J.* ; Eslam, M.* ; Chen, F.W.* ; Rubets, E.* ; Markov, A.G.* ; Weiss, N.* ; Birkenfeld, A.L. ; Schwarz, P.E. ; Bode-Böger, S.M.* ; Perakakis, N. ; O'Sullivan, J.F.* ; George, J.*

Symmetric dimethylguanidino valeric acid, a novel single biomarker of hepatic steatosis.

iScience 27:111366 (2024)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
There is an unmet need for a biomarker of liver fat. We identified dimethylguanidino valeric acid (DMGV) as a circulating biomarker of liver fat. Here, we assess its two isoforms—symmetric (SDGV) and asymmetric (ADGV)—as biomarkers of steatosis. We determined plasma ADGV, SDGV, related metabolites, alanine aminotransferase (ALT), and the fatty liver index (FLI) in two cohorts and compared their diagnostic performance for liver fat detection. SDGV was the strongest predictor of moderate to severe steatosis. Changes in SDGV correlated with changes in liver fat % in a prospective cohort. In a murine model of fatty liver disease, protein levels and activity of alanine:glyoxylate aminotransferase 2 (AGXT2), which produces SDGV, were increased and coincided with elevation of SDGV concentrations. SDGV is a biomarker of liver fat and its increase in hepatic steatosis results from the upregulation of AGXT2 activity.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Clinical Finding ; Health Sciences ; Physiological State; Fatty Liver; Human Plasma; Enzyme; Quantification; Arginine; Agxt2
Sprache englisch
Veröffentlichungsjahr 2024
HGF-Berichtsjahr 2024
ISSN (print) / ISBN 2589-0042
e-ISSN 2589-0042
Zeitschrift iScience
Quellenangaben Band: 27, Heft: 12, Seiten: , Artikelnummer: 111366 Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam ; Bosten ; London ; New York ; Oxford ; Paris ; Philadelphia ; San Diego ; St. Louis
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
Institute of Pancreatic Islet Research (IPI)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502400-001
G-502600-004
G-502600-012
Förderungen Cancer Institute, NSW grant
NHMRC-MRFF CVD grant
National Heart Foundation
Federal Ministry of Education and Research (BMBF)
Robert W. Storr Bequest
National Health and Medical Research Council of Australia (NHMRC)
NSW Office of Medical Health and Research
DOI 10.1016/j.isci.2024.111366
WOS ID 001367443400001
Scopus ID 85210019525
PubMed ID 39660051
Erfassungsdatum 2024-12-02
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