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Rodionov, R.N.* ; Jarzebska, N.* ; Koay, Y.C.* ; Li, M.* ; Kuhn, M.* ; Bornstein, S.R.* ; Martens-Lobenhoffer, J.* ; Eslam, M.* ; Chen, F.W.* ; Rubets, E.* ; Markov, A.G.* ; Weiss, N.* ; Birkenfeld, A.L. ; Schwarz, P.* ; Bode-Böger, S.M.* ; Perakakis, N.* ; O'Sullivan, J.F.* ; George, J.*

Symmetric dimethylguanidino valeric acid, a novel single biomarker of hepatic steatosis.

iScience 27:111366 (2024)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
There is an unmet need for a biomarker of liver fat. We identified dimethylguanidino valeric acid (DMGV) as a circulating biomarker of liver fat. Here, we assess its two isoforms—symmetric (SDGV) and asymmetric (ADGV)—as biomarkers of steatosis. We determined plasma ADGV, SDGV, related metabolites, alanine aminotransferase (ALT), and the fatty liver index (FLI) in two cohorts and compared their diagnostic performance for liver fat detection. SDGV was the strongest predictor of moderate to severe steatosis. Changes in SDGV correlated with changes in liver fat % in a prospective cohort. In a murine model of fatty liver disease, protein levels and activity of alanine:glyoxylate aminotransferase 2 (AGXT2), which produces SDGV, were increased and coincided with elevation of SDGV concentrations. SDGV is a biomarker of liver fat and its increase in hepatic steatosis results from the upregulation of AGXT2 activity.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Clinical Finding ; Health Sciences ; Physiological State; Fatty Liver; Human Plasma; Enzyme; Quantification; Arginine; Agxt2
ISSN (print) / ISBN 2589-0042
e-ISSN 2589-0042
Zeitschrift iScience
Quellenangaben Band: 27, Heft: 12, Seiten: , Artikelnummer: 111366 Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam ; Bosten ; London ; New York ; Oxford ; Paris ; Philadelphia ; San Diego ; St. Louis
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
Förderungen Cancer Institute, NSW grant
NHMRC-MRFF CVD grant
National Heart Foundation
Federal Ministry of Education and Research (BMBF)
Robert W. Storr Bequest
National Health and Medical Research Council of Australia (NHMRC)
NSW Office of Medical Health and Research