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Rosenberger, A.* ; Bickeböller, H.* ; McCormack, V.* ; Brenner, D.R.* ; Duell, E.J.* ; Tjønneland, A.* ; Friis, S.* ; Muscat, J.E.* ; Yang, P.* ; Wichmann, H.-E. ; Heinrich, J. ; Szeszenia-Dabrowska, N.* ; Lissowska, J.* ; Zaridze, D.* ; Rudnai, P.* ; Fabianova, E.* ; Janout, V.* ; Bencko, V.* ; Brennan, P.* ; Mates, D.* ; Schwartz, A.G.* ; Cote, M.L.* ; Zhang, Z.F.* ; Morgenstern, H.* ; Oh, S.S.* ; Field, J.K.* ; Raji, O.* ; McLaughlin, J.R.* ; Wiencke, J.* ; LeMarchand, L.* ; Neri, M.* ; Bonassi, S.* ; Andrew, A.S.* ; Lan, Q.* ; Hu, W.* ; Orlow, I.* ; Park, B.J.* ; Boffetta, P.* ; Hung, R.J.*

Asthma and lung cancer risk: A systematic investigation by the International Lung Cancer Consortium.

Carcinogenesis 33, 587-597 (2012)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Asthma has been hypothesized to be associated with lung cancer (LC) risk. We conducted a pooled analysis of 16 studies in the International Lung Cancer Consortium (ILCCO) to quantitatively assess this association and compared the results with 36 previously published studies. In total, information from 585 444 individuals was used. Study-specific measures were combined using random effects models. A meta-regression and subgroup meta-analyses were performed to identify sources of heterogeneity. The overall LC relative risk (RR) associated with asthma was 1.28 [95% confidence intervals (CIs) = 1.16-1.41] but with large heterogeneity (I(2) = 73%, P < 0.001) between studies. Among ILCCO studies, an increased risk was found for squamous cell (RR = 1.69, 95%, CI = 1.26-2.26) and for small-cell carcinoma (RR = 1.71, 95% CI = 0.99-2.95) but was weaker for adenocarcinoma (RR = 1.09, 95% CI = 0.88-1.36). The increased LC risk was strongest in the 2 years after asthma diagnosis (RR = 2.13, 95% CI = 1.09-4.17) but subjects diagnosed with asthma over 10 years prior had no or little increased LC risk (RR = 1.10, 95% CI = 0.94-1.30). Because the increased incidence of LC was chiefly observed in small cell and squamous cell lung carcinomas, primarily within 2 years of asthma diagnosis and because the association was weak among never smokers, we conclude that the association may not reflect a causal effect of asthma on the risk of LC.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Obstructive pulmonary-disease; Nonmalignant respiratory conditions; United-states; Never-smokers; Nonsmoking women; Family-history; Prospective cohort; Resdential radon; Distinct diseases; Meta-regression
ISSN (print) / ISBN 0143-3334
e-ISSN 1460-2180
Zeitschrift Carcinogenesis
Quellenangaben Band: 33, Heft: 3, Seiten: 587-597 Artikelnummer: , Supplement: ,
Verlag Oxford University Press
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)