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Kampalli, P.K.* ; Ghanta, M.K.* ; Verma, H.K. ; Alam, A.* ; Peela, S.* ; Bhaskar, L.V.K.S.*

Exploring the relationship between ERCC1 polymorphisms and colorectal cancer risk: Insights from an in-depth meta-analysis.

Hum. Gene 43:201361 (2025)

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Introduction: In recent decades, there has been mounting evidence linking Excision repair cross-complementing gene (ERCC1) polymorphisms to colorectal cancer (CRC). According to recent epidemiological research, the ERCC1 polymorphism may have an impact on the incidence of colorectal cancer (CRC). However, there is controversy on ERCC1 genetic variants affecting CRC in these studies. Hence, this meta-analysis study aimed to analyze the link between CRC and ERCC1 gene polymorphism. Methodology: We looked up information on the impact of ERCC1 genetic variations on CRC development in the Web of Science, PubMed, and Embase. Addressing the risk of colorectal cancer associated with mutations in the ERCC1 gene, no meta-analysis was conducted. Using Stata (version 12.0) applications, we effectively conducted a meta-analysis of thirteen case-control investigations and integrated the pooled odds ratios (ORs) according to a 95 % confidence interval (CI) of the overall and subgroup analysis. Results: According to our findings, there appears to have been a noteworthy association found between rs3212986 and the risk of CRC in both the allele genetic model (OR 95 % CI = 1:44 (1.21–1.71) and the dominant genetic model (OR 95 % CI = 1:04 (0.93–1.15) for overall CRC. Conclusion: In conclusion, the results of this meta-analysis showed that rs3212986 polymorphism was significantly associated with colorectal cancer risk, whereas rs11615 polymorphism was not significantly associated with colorectal cancer risk.

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