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Assessing cancer risks of low-dose radiation.
Nat. Rev. Cancer 9, 596-604 (2009)
Ionizing radiation is considered a non-threshold carcinogen. However, quantifying the risk of the more commonly encountered low and/or protracted radiation exposures remains problematic and subject to uncertainty. Therefore, a major challenge lies in providing a sound mechanistic understanding of low-dose radiation carcinogenesis. This Perspective article considers whether differences exist between the effects mediated by high- and low-dose radiation exposure and how this affects the assessment of low-dose cancer risk.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
atomic-bomb survivors; double-strand breaks; ionizing-radiation; dna-damage; in-vivo; gene-expression; hyper-radiosensitivity; telomere dysfunction; human-cells; interventional radiology
ISSN (print) / ISBN
1474-175X
e-ISSN
1474-1768
Zeitschrift
Nature Reviews - Cancer
Quellenangaben
Band: 9,
Heft: 8,
Seiten: 596-604
Verlag
Nature Publishing Group
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed