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Griciuc, A. ; Aron, L.* ; Ueffing, M.

Looking into eyes: Rhodopsin pathologies in Drosophila.

Adv. Exp. Med. Biol. 723, 415-423 (2012)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The detailed examination of eye structure and function in numerous Drosophila mutants has provided unprecedented insights into retinal physiology and pathology. Many Drosophila mutants that undergo retinal degeneration (RD) exhibit structural and/or dynamic alterations of the photon receptor rhodopsin, and similar defects cause retinitis pigmentosa (RP) in humans. Here, we consider how the use of Drosophila has advanced our understanding of RP and highlight new mechanisms underlying rhodopsin-mediated pathologies in the retina.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Retinitis pigmentosa; Retinal degeneration; Rhodopsin; Drosophila; Photoreceptor; Retina; Phototransduction; Autophagy; ER stress
ISSN (print) / ISBN 0065-2598
ISBN 978-1-4614-0630-3
Zeitschrift Advances in Experimental Medicine and Biology
Quellenangaben Band: 723, Heft: 6, Seiten: 415-423 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort New York
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) CF Metabolomics & Proteomics (CF-MPC)