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Hense, B.A. ; Müller, J.* ; Kuttler, C.* ; Hartmann, A.

Spatial heterogeneity of autoinducer regulation systems.

Sensors 12, 4156-4171 (2012)
Verlagsversion Volltext DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Autoinducer signals enable coordinated behaviour of bacterial populations, a phenomenon originally described as quorum sensing. Autoinducer systems are often controlled by environmental substances as nutrients or secondary metabolites (signals from neighbouring organisms. In cell aggregates and biofilms gradients of signals and environmental substances emerge. Mathematical modelling is used to analyse the functioning of the system. We find that the autoinducer regulation network generates spatially heterogeneous behaviour, up to a kind of multicellularity-like division of work, especially under nutrient-controlled conditions. A hybrid push/pull concept is proposed to explain the ecological function. The analysis allows to explain hitherto seemingly contradicting experimental findings.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter autoinducer regulation network; spatial heterogeneity; division of work; hybrid push/pull control; quorum sensing
ISSN (print) / ISBN 1424-8220
e-ISSN 1424-8220
Zeitschrift Sensors
Quellenangaben Band: 12, Heft: 4, Seiten: 4156-4171 Artikelnummer: , Supplement: ,
Verlag MDPI
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biomathematics and Biometry (IBB)
Research Unit Microbe-Plant Interactions (AMP)