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Liang, W. ; Stubbe, M.* ; Pleninger, L. ; Hofferek, A.* ; Stubbe, H.C.* ; Mai, J.* ; Özer, S. ; Frishman, D.* ; Schreiner, S. ; Vincendeau, M.

HERV reactivation by adenovirus infection is associated with viral immune regulation.

Microbes Infect. 27:105466 (2024)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Human endogenous retroviruses (HERVs), which are normally silenced by methylation or mutation, can be reactivated by a variety of environmental factors, including infection with exogenous viruses. In this work, we investigated the transcriptional activity of HERVs following infection of human liver cells (HepaRG) with human adenovirus C serotype 5 (HAdV-C5). HAdV-C5 infection results in reactivation of several HERV groups as well as differentially expressed genes. Interestingly, in HAdV-C5 infection, upregulated genes that were in close chromosomal proximity to upregulated HERV loci were associated with influencing viral carcinogenesis and inflammatory signaling. We also identified an FBXO17 transcript encoding an intronic ERVK9-11 sense sequence upon HAdV-C5 infection. FBXO17 has previously been described as an important factor in the regulation of the interferon response. This suggests that specific HERV groups may have the potential to trigger gene networks and influence viral immune responses.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Erv-k9 ; Fbxo17 ; Hadv-c5 ; Hervs ; Human Adenovirus ; Inf Response ; Differentially Expressed Hervs ; Differentially Expressed Genes ; Functional Annotation ; Gene Regulation ; Virus-host Interactions; Human Endogenous Retroviruses; E1b-55k Protein; Cell-line; Expression; Evolution; Growth
Sprache englisch
Veröffentlichungsjahr 2024
HGF-Berichtsjahr 2024
ISSN (print) / ISBN 1286-4579
e-ISSN 1769-714X
Zeitschrift Microbes and Infection
Quellenangaben Band: 27, Heft: 5-6, Seiten: , Artikelnummer: 105466 Supplement: ,
Verlag Elsevier
Verlagsort Radarweg 29, 1043 Nx Amsterdam, Netherlands
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Virology (VIRO)
POF Topic(s) 30203 - Molecular Targets and Therapies
Forschungsfeld(er) Immune Response and Infection
PSP-Element(e) G-502700-009
G-502700-007
Förderungen Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)
Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy-EXC
Sachbeihilfe
Deutsche Forschungsgemeinschaft
DOI 10.1016/j.micinf.2024.105466
WOS ID 001608157800001
Scopus ID 85213990463
PubMed ID 39716530
Erfassungsdatum 2025-01-09
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