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Kopaliani, I.* ; Elsaid, B.* ; Speier, S. ; Deussen, A.*

Immune and metabolic mechanisms of endothelial dysfunction.

Int. J. Mol. Sci. 25:13337 (2024)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Endothelial dysfunction is a strong prognostic factor in predicting the development of cardiovascular diseases. Dysfunctional endothelium loses its homeostatic ability to regulate vascular tone and prevent overactivation of inflammation, leading to vascular dysfunction. These functions are critical for vascular homeostasis and arterial pressure control, the disruption of which may lead to hypertension. Hypertension itself can also cause endothelial dysfunction, as endothelial cells are susceptible to haemodynamic changes. Although it is unclear which of those factors appear first, they create a vicious circle further damaging multiple organs, including the heart and vessels. There are also sex-specific differences in homeostatic functions of the endothelium regarding vessel tone regulation, which may contribute to differences in arterial blood pressure between men and women. Even more importantly, there are sex-differences in the development of endothelial dysfunction and vessel remodelling. Hence, an understanding of the mechanisms of endothelial dysfunction and its contribution to pathological vascular remodelling during hypertension is of critical importance. This review addresses immunological and metabolic aspects in mechanisms of endothelial dysfunction and the resulting mechanisms in vascular remodelling with respect to arterial hypertension, including the potential role of sex-specific differences.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Endothelial Dysfunction ; Endothelium ; Hypertension ; Inflammation ; Metabolism ; Sex-differences ; Vessel Remodelling; Vascular Smooth-muscle; Porcine Coronary-arteries; Nitric-oxide Synthesis; Angiotensin-ii; Blood-pressure; Asymmetric Dimethylarginine; Gender-differences; Cardiac Rehabilitation; Hyperpolarizing Factor; Sex-differences
Sprache englisch
Veröffentlichungsjahr 2024
HGF-Berichtsjahr 2024
ISSN (print) / ISBN 1661-6596
e-ISSN 1422-0067
Zeitschrift International Journal of Molecular Sciences
Quellenangaben Band: 25, Heft: 24, Seiten: , Artikelnummer: 13337 Supplement: ,
Verlag MDPI
Verlagsort Basel
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Pancreatic Islet Research (IPI)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502600-005
Förderungen Deutsche Forschungsgemeinschaft
Irakli Kopaliani from the Deutsche Forschungsgemeinschaft
DOI 10.3390/ijms252413337
WOS ID 001384908500001
Scopus ID 85213217359
PubMed ID 39769104
Erfassungsdatum 2025-01-10
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