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Miranda-Cervantes, A.* ; Fritzen, A.M.* ; Raun, S.H.* ; Hodek, O.* ; Møller, L.L.V.* ; Johann, K.* ; Deisen, L.* ; Gregorevic, P.* ; Gudiksen, A.* ; Artati, A. ; Adamski, J. ; Andersen, N.R.* ; Sigvardsen, C.M.* ; Carl, C.S.* ; Voldstedlund, C.T.* ; Kjøbsted, R.* ; Hauck, S.M. ; Schjerling, P.* ; Jensen, T.E.* ; Cebrian Serrano, A. ; Jähnert, M.* ; Gottmann, P.* ; Burtscher, I. ; Lickert, H. ; Pilegaard, H.* ; Schürmann, A.* ; Tschöp, M.H. ; Moritz, T.* ; Müller, T.D. ; Sylow, L.* ; Kiens, B.* ; Richter, E.A.* ; Kleinert, M.

Pantothenate kinase 4 controls skeletal muscle substrate metabolism.

Nat. Commun. 16:345 (2025)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Metabolic flexibility in skeletal muscle is essential for maintaining healthy glucose and lipid metabolism, and its dysfunction is closely linked to metabolic diseases. Exercise enhances metabolic flexibility, making it an important tool for discovering mechanisms that promote metabolic health. Here we show that pantothenate kinase 4 (PanK4) is a new conserved exercise target with high abundance in muscle. Muscle-specific deletion of PanK4 impairs fatty acid oxidation which is related to higher intramuscular acetyl-CoA and malonyl-CoA levels. Elevated acetyl-CoA levels persist regardless of feeding state and are associated with whole-body glucose intolerance, reduced insulin-stimulated glucose uptake in glycolytic muscle, and impaired glucose uptake during exercise. Conversely, increasing PanK4 levels in glycolytic muscle lowers acetyl-CoA and enhances glucose uptake. Our findings highlight PanK4 as an important regulator of acetyl-CoA levels, playing a key role in both muscle lipid and glucose metabolism.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Stimulated Glucose-transport; Insulin-resistance; Malonyl-coa; Exercise; Coenzyme; Ampk; Inflammation; Oxidation; Proteome; Reveals
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Zeitschrift Nature Communications
Quellenangaben Band: 16, Heft: 1, Seiten: , Artikelnummer: 345 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)
CF Metabolomics & Proteomics (CF-MPC)
Institute of Experimental Genetics (IEG)
Institute of Diabetes and Regeneration Research (IDR)
Förderungen Deutsche Forschungsgemeinschaft (DFG)
Danish Diabetes Academy
Novo Nordisk Foundation
Independent Research Fund Denmark
Lundbeck Foundation
National Health and Medical Research Council of Australia
German Research Foundation
German Center for Diabetes Research
European Research Council
Danish Council for Independent Research, Medical Sciences
Novo Nordisk Fonden (Novo Nordisk Foundation)