PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Semmler-Behnke, M. ; Kreyling, W.G. ; Schulz, H. ; Takenaka, S. ; Butler, J.P.* ; Henry, F.S.* ; Tsuda, A.*

Nanoparticle delivery in infant lungs.

Proc. Natl. Acad. Sci. U.S.A. 109, 5092-5097 (2012)
Verlagsversion Volltext DOI PMC
Open Access Gold
The lung surface is an ideal pathway to the bloodstream for nanoparticle-based drug delivery. Thus far, research has focused on the lungs of adults, and little is known about nanoparticle behavior in the immature lungs of infants. Here, using nonlinear dynamical systems analysis and in vivo experimentation in developing animals, we show that nanoparticle deposition in postnatally developing lungs peaks at the end of bulk alveolation. This finding suggests a unique paradigm, consistent with the emerging theory that as alveoli form through secondary septation, alveolar flow becomes chaotic and chaotic mixing kicks in, significantly enhancing particle deposition. This finding has significant implications for the application of nanoparticle-based inhalation therapeutics in young children with immature lungs from birth to 2 y of age.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
9.681
0.807
44
56
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter postnatal lung development; inhalation therapy; pulmonary acinus; aerosol transport and deposition; convective mixing
Sprache englisch
Veröffentlichungsjahr 2012
HGF-Berichtsjahr 2012
ISSN (print) / ISBN 0027-8424
e-ISSN 1091-6490
Zeitschrift Proceedings of the National Academy of Sciences of the United States of America
Quellenangaben Band: 109, Heft: 13, Seiten: 5092-5097 Artikelnummer: , Supplement: ,
Verlag National Academy of Sciences
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Lung Health and Immunity (LHI)
Institute of Epidemiology (EPI)
POF Topic(s)
30503 - Chronic Diseases of the Lung and Allergies
Forschungsfeld(er)
Lung Research
Genetics and Epidemiology
PSP-Element(e) G-505000-002
G-505000-009
G-503900-003
PubMed ID 22411799
DOI 10.1073/pnas.1119339109
WOS ID WOS:000302164200076
Scopus ID 84859451126
Erfassungsdatum 2012-04-19
[➜Korrektur melden]