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Lehmann, M. ; Krishnan, R.* ; Sucre, J.* ; Kulkarni, H.S.* ; Pineda, R.H.* ; Anderson, C.* ; Banovich, N.E.* ; Behrsing, H.P.* ; Dean, C.H.* ; Haak, A.* ; Gosens, R.* ; Kaminski, N.* ; Zagorska, A.* ; Koziol-White, C.* ; Metcalf, J.P.* ; Kim, Y.H.* ; Loebel, C.* ; Neptune, E.R.* ; Noël, A.* ; Raghu, G.* ; Sewald, K.* ; Sharma, A.* ; Suki, B.* ; Sperling, A.* ; Tatler, A.* ; Turner, S.* ; Rosas, I.O.* ; Pam Van, R.Y.* ; Wille, T.* ; Randell, S.H.* ; Pryhuber, G.* ; Rojas, M.* ; Bourke, J.* ; Königshoff, M.*

Precision-cut lung slices: Emerging tools for preclinical and translational lung research an official american thoracic society workshop report.

Am. J. Respir. Cell Mol. Biol. 72, 16-31 (2025)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The urgent need for effective treatments for acute and chronic lung diseases underscores the significance of developing innovative preclinical human research tools. The 2023 American Thoracic Society Workshop on Precision-Cut Lung Slices (PCLSs) brought together 35 experts to discuss and address the role of human tissue–derived PCLSs as a unique tool for target and drug discovery and validation in pulmonary medicine. With increasing interest and usage, together with advancements in methods and technology, there is a growing need for consensus on PCLS methodology and readouts. The current document recommends standard reporting criteria and emphasizes the requirement for careful collection and integration of clinical metadata. We further discuss current clinically relevant readouts that can be applied to PCLSs and highlight recent developments and future steps for implementing novel technologies for PCLS modeling and analysis. The collection and correlation of clinical metadata and multiomic analysis will further advance the integration of this preclinical platform into patient endotyping and the development of tailored therapies for patients with lung disease.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Biomarkers ; Human Ex Vivo Model ; Precision-cut Lung Slice ; Preclinical Research ; Translational Research; Organ-culture; Human Airway; Tissue; Model; Contraction; Cell; Inhibitor; Infection; Responses; Repair
ISSN (print) / ISBN 1044-1549
e-ISSN 1535-4989
Zeitschrift American Journal of Respiratory Cell and Molecular Biology
Quellenangaben Band: 72, Heft: 1, Seiten: 16-31 Artikelnummer: , Supplement: ,
Verlag American Thoracic Society
Verlagsort 25 Broadway, 18 Fl, New York, Ny 10004 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Lung Health and Immunity (LHI)
Förderungen Three Lakes Foundation
von Behring R_ontgen Foundation
Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)
German Center for Lung Research (DZL)