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Ear, P.H.* ; Marinoni, I.* ; Dayton, T.* ; Guenter, R.* ; Quelle, D.E.* ; Battistella, A.* ; Buishand, F.O.* ; Chittaranjan, S.* ; Nancy Du, Y.C.* ; Marques, I.* ; Pellegata, N.S. ; Sadowski, S.M.* ; Tirosh, A.* ; April-Monn, S.L.* ; Aurilia, C.* ; Jaskula-Sztul, R.* ; Baena Moreno, M.J.* ; Donati, S.* ; English, K.A.* ; Hernandez Llorens, M.A.* ; Hodgetts, H.* ; Marini, F.* ; Martins, M.L.* ; Palmini, G.* ; Soldevilla, B.* ; Schrader, J.* ; Thakker, R.V.* ; Lines, K.E.*

NET Models Meeting 2024 white paper: The current state of neuroendocrine tumour research models and our future aspirations.

Endocr. Oncol. 4:e240055 (2024)
Verlagsversion DOI PMC
Free journal
Creative Commons Lizenzvertrag
Current models for the study of neuroendocrine tumours (NETs) are severely limited. While in vitro (e.g. cell lines), ex vivo (e.g. organoids) and in vivo (e.g. mice) models all exist, each has limitations. To address these limitations and collectively identify strategies to move the NET models field forward, we held an inaugural NET models meeting, hosted by our founding group: Dr Lines (Oxford), Prof. Quelle (Iowa), Dr Dayton (Barcelona), Dr Ear (Iowa), Dr Marinoni (Bern) and Dr Guenter (Alabama). This two-day meeting in Oxford (UK) was organised and supported by Bioscientifica Ltd and was solely dedicated to the discussion of NET models. The meeting was attended by ∼30 international researchers (from the UK, EU, Israel, USA and Canada). Plenary talks were given by Prof. Thakker, who summarised NET research over the past few decades, and Dr Schrader, who described the process and pitfalls of generating new cell lines. Eight researchers also presented their work on topics ranging from human cell 3D bioprinting to zebrafish models and included novel ideas and improvements on current concepts. This was followed by an interactive workshop, where discussion topics included a summary of currently available NET models, limitations of these models, barriers to developing new models, and how we can address these issues going forward. This white paper summarises the key points raised in these discussions and the future aspirations of the NET Models Consortium. The next meeting will take place in Oxford (UK) in 2025; contact contact@netcancerfoundation.com for more information.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Consortium ; Ex Vivo ; In Vitro ; In Vivo
ISSN (print) / ISBN 2634-4793
e-ISSN 2634-4793
Zeitschrift Endocrine Oncology
Quellenangaben Band: 4, Heft: 1, Seiten: , Artikelnummer: e240055 Supplement: ,
Verlag Bioscientifica Ltd.
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Cancer (IDC)