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Physiologische und pathophysiologische Veränderungen der alternden Lunge.
Physiological and pathophysiological changes of the ageing lung.
Z. Gerontol. Geriatr. 58, 85-90 (2025)
BACKGROUND: Due to age-related changes the lung function decreases. At the same time there is an increase in pulmonary diseases that lead to restrictions in mobility and autonomy. RESEARCH QUESTION: What are the underlying changes in lung ageing? To what extent do they affect lung function and are there factors that can be influenced? METHOD: Literature search. RESULTS: Ageing of the lungs is associated with a loss of elasticity and distensibility. Senescence-associated factors play an important role at the molecular level. Accumulation of damaged DNA and proteins, oxidative stress and chronic inflammation are major factors. Avoidance of harmful environmental factors can reduce the disease burden. CONCLUSION: Age-related pathophysiological changes lead to increased work of breathing with decreasing muscle strength. Patients should be encouraged to avoid inhaling noxious agents as these are associated with a diminution of lung function loss even in older age.
Impact Factor
Scopus SNIP
Altmetric
1.000
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Anmerkungen
Besondere Publikation
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
Cellular Senescence ; Infammation ; Mitochondrial Dysfunction ; Oxidative Stress ; Work Of Breathing; Cellular Senescence; Consequences; Dysfunction; Phenotype; Mechanism; Hallmarks
Sprache
deutsch
Veröffentlichungsjahr
2025
HGF-Berichtsjahr
2025
ISSN (print) / ISBN
0948-6704
e-ISSN
1435-1269
Zeitschrift
Zeitschrift für Gerontologie und Geriatrie
Quellenangaben
Band: 58,
Heft: 2,
Seiten: 85-90
Verlag
Springer
Verlagsort
Heidelberg
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Lung Health and Immunity (LHI)
POF Topic(s)
30202 - Environmental Health
Forschungsfeld(er)
Lung Research
PSP-Element(e)
G-501600-005
WOS ID
001401910400001
Scopus ID
85217248306
PubMed ID
39833352
Erfassungsdatum
2025-03-24