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Mekonnen, D.W. ; Ghirardo, A. ; Zhang, W. ; Schäffner, A.

The branched-chain amino acid-related isoleucic acid: recent research advances.

Plant Biol. 27, 195-202 (2025)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Isoleucic acid (ILA) was identified in human patients with maple syrup urine disease (MSUD) half a century ago. MSUD patients, who are defective in the catabolism of branched-chain amino acids (BCAAs), that is, isoleucine, leucine, and valine, have urine with a unique maple syrup odour related to the accumulation of BCAA breakdown products, largely 2-keto acid derivatives and their reduced 2-hydroxy acids including ILA. A decade ago, ILA was identified in Arabidopsis thaliana. Subsequent studies in other plant species indicated that ILA is a ubiquitously present compound. Since its identification in plants, several efforts have been made to understand the biological significance and metabolic pathway of ILA. ILA plays a positive role in plant signalling for defence responses against bacterial pathogens by increasing the abundance of salicylic acid aglycone through competitive inhibition of SA deactivation by glucosylation. Here, we review recent progress in the characterization of ILA biosynthesis and function in plants and discuss current knowledge gaps and future directions in ILA research.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter 2‐hydroxy Acid ; 2‐keto Acid ; Bcat ; Bckdh ; Ila ; Kmva; Syrup-urine-disease; Arabidopsis-glyoxylate Reductase; Systemic Acquired-resistance; N-hydroxypipecolic Acid; Hydroxy-pipecolic Acid; Substrate-specificity; Plant Defense; Dehydrogenase; Ugt76b1; Growth
Sprache englisch
Veröffentlichungsjahr 2025
HGF-Berichtsjahr 2025
ISSN (print) / ISBN 1435-8603
e-ISSN 1438-8677
Zeitschrift Plant Biology
Quellenangaben Band: 27, Heft: 2, Seiten: 195-202 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort 111 River St, Hoboken 07030-5774, Nj Usa
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Environmental Simulation (EUS)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Environmental Sciences
PSP-Element(e) G-504900-007
G-504991-001
Förderungen Projekt DEAL
DOI 10.1111/plb.13771
WOS ID 001470144500012
Scopus ID 85215580072
PubMed ID 39844635
Erfassungsdatum 2025-03-24
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