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Bocchi, R. ; Thorwirth, M. ; Simon-Ebert, T. ; Koupourtidou, C.* ; Clavreul, S. ; Kolf, K.* ; Della Vecchia, P.* ; Bottes, S.* ; Jessberger, S.* ; Zhou, J.* ; Wani, G. ; Pilz, G.A.* ; Ninkovic, J. ; Buffo, A.* ; Sirko, S. ; Götz, M. ; Fischer-Sternjak, J.

Astrocyte heterogeneity reveals region-specific astrogenesis in the white matter.

Nat. Neurosci. 28, 457-469 (2025)
Verlagsversion Forschungsdaten DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Astrocyte heterogeneity has been well explored, but our understanding of white matter (WM) astrocytes and their distinctions from gray matter (GM) astrocytes remains limited. Here, we compared astrocytes from cortical GM and WM/corpus callosum (WM/CC) using single-cell RNA sequencing and spatial transcriptomics of the murine forebrain. The comparison revealed similarities but also significant differences between WM and GM astrocytes, including cytoskeletal and metabolic hallmarks specific to WM astrocytes with molecular properties also shared with human WM astrocytes. When we compared murine astrocytes from two different WM regions, the cortex and cerebellum, we found that they exhibited distinct, region-specific molecular properties, with the cerebellum lacking, for example, a specific cluster of WM astrocytes expressing progenitor and proliferation genes. Functional experiments confirmed astrocyte proliferation in the WM/CC, but not in the cerebellar WM, suggesting that the WM/CC may be a source of continued astrogenesis.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Adult; Astroglia; Neurons; Glia
Sprache englisch
Veröffentlichungsjahr 2025
HGF-Berichtsjahr 2025
ISSN (print) / ISBN 1097-6256
e-ISSN 1546-1726
Zeitschrift Nature Neuroscience
Quellenangaben Band: 28, Heft: 3, Seiten: 457-469 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort Heidelberger Platz 3, Berlin, 14197, Germany
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Stem Cell Research (ISF)
POF Topic(s) 30204 - Cell Programming and Repair
Forschungsfeld(er) Stem Cell and Neuroscience
PSP-Element(e) G-500800-001
Förderungen Swiss National Science Foundation (SNF)
Deutsche Forschungsgemeinschaft
German Research Foundation, within the programs ImmunoStroke
Checkpoints of Central Nervous System Recovery
Munich Cluster for Systems Neurology (SyNergy)
European Research Council
EU
SNF postdoctoral fellowship
Schweizerischer Nationalfonds zur Frderung der Wissenschaftlichen Forschung (Swiss National Science Foundation)
DOI 10.1038/s41593-025-01878-6
WOS ID 001429056900001
Scopus ID 85218705989
PubMed ID 39994409
Erfassungsdatum 2025-04-15
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