PuSH - Publikationsserver des Helmholtz Zentrums München

Eberlein, B.* ; Brockow, K.* ; Darsow, U.* ; Biedermann, T.* ; Blank, S.

Basophil activation test in Hymenoptera venom allergy.

Allergologie 48, 84-90 (2025)
DOI
Systemic reactions to Hymenoptera venoms require an allergological work-up before starting venom specific immunotherapy (VIT) in order to prove an IgE-mediated reaction and identify the culprit insect venom. In addition to skin tests and the determination of specific IgE antibodies, the basophil activation test (BAT) using flow cytometry has developed into a powerful test and sensitive marker for this purpose in recent years. Compared to the other tests, the BAT seems to have a better informative value in terms of clinical relevance. In Hymenoptera venom allergies, BAT is particularly useful for the diagnosis of cases with unclear or contradictory history or sensitization profile. Its results are related to adverse reactions during immunotherapy and its efficacy. They therefore have a certain predictive value for side effects and treatment success of VIT. In research, BAT is mainly used to characterize the allergenic components of Hymenoptera venoms. This review article focuses on these topics.
Altmetric
Weitere Metriken?
[➜Einloggen]
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Basophil Activation Test ; Component-resolved Diagnosis ; Hymenoptera Venom Allergy ; Venom Specific Immunotherapy (vit)
ISSN (print) / ISBN 0344-5062
e-ISSN 0344-5062
Zeitschrift Allergologie
Quellenangaben Band: 48, Heft: 2, Seiten: 84-90 Artikelnummer: , Supplement: ,
Verlag Dustri
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Allergy Research (IAF)