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Avci, M.Y.* ; Chan, E. ; Zimmer, V.* ; Rueckert, D.* ; Wiestler, B.* ; Schnabel, J.A. ; Bercea, C.-I.

Unsupervised analysis of Alzheimer’s disease signatures using 3D deformable autoencoders.

In: (Medical Information Computing). Springer, 2025. 266-276 (Comm. Comp. Info. Sci. ; 2240)
DOI
With the increasing incidence of neurodegenerative diseases such as Alzheimer’s Disease (AD), there is a need for further research that enhances detection and monitoring of the diseases. We present MORPHADE (Morphological Autoencoders for Alzheimer’s Disease Detection), a novel unsupervised learning approach which uses deformations to allow the analysis of 3D T1-weighted brain images. To the best of our knowledge, this is the first use of deformations with deep unsupervised learning to not only detect, but also localize and assess the severity of structural changes in the brain due to AD. We obtain markedly higher anomaly scores in clinically important areas of the brain in subjects with AD compared to healthy controls, showcasing that our method is able to effectively locate AD-related atrophy. We additionally observe a visual correlation between the severity of atrophy highlighted in our anomaly maps and medial temporal lobe atrophy scores evaluated by a clinical expert. Finally, our method achieves an AUROC of 0.80 in detecting AD, out-performing several supervised and unsupervised baselines. We believe our framework shows promise as a tool towards improved understanding, monitoring and detection of AD. To support further research and application, we have made our code publicly available at github.com/ci-ber/MORPHADE.
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Publikationstyp Artikel: Konferenzbeitrag
Korrespondenzautor
Schlagwörter Classification ; Registration ; Unsupervised Learning
ISSN (print) / ISBN 1865-0929
e-ISSN 1865-0937
Konferenztitel Medical Information Computing
Zeitschrift Communications in Computer and Information Science
Quellenangaben Band: 2240, Heft: , Seiten: 266-276 Artikelnummer: , Supplement: ,
Verlag Springer
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Machine Learning in Biomed Imaging (IML)