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Wahl, L.* ; Rau, S.* ; Dawczynski, C.A.* ; Lorkowski, S.* ; Ulrich, R.* ; Blüher, M. ; Vervuert, I.*

Type of diet has no major influence on inflammatory response in a Saddleback pig model.

Sci. Rep. 15:8381 (2025)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Fermentable carbohydrates and resulting short-chain fatty acids (SCFAs) received attention via modifying potential on obesity-associated systemic low-grade inflammation. However, their effects on inflammation remain poorly understood. In this study, the anti-inflammatory properties of pectin or inulin supplementation were investigated in an atherogenic-fed pig obesity model. Pigs were divided into three atherogenic-fed groups with or without 5% pectin/inulin supplementation (AD, ADp, ADi, n = 10) and a conventional-fed group (CD, n = 10) for a 15-week feeding period. We demonstrated that faecal SCFA concentrations decreased and faecal pH increased in all groups over the feeding period (P < 0.05). SCFA concentrations were comparable between colon and faeces in all groups. Liver inflammatory-marker expressions were on average < 1 in all groups, except TNF-α (AD < CD and ADi; P < 0.01). Inflammatory-marker expressions in abdominal adipose tissue exceeded subcutaneous marker expressions in all groups. AD showed significantly lower IL-1β and CD68 mRNA levels than CD (P < 0.03). Comparing the atherogenic diet groups, the IL-1β mRNA levels were higher in ADi versus AD and ADp (P = 0.02). Our data indicated that fermentable carbohydrates added to an atherogenic diet cannot resolve low-grade adipose tissue inflammatory associated with obesity.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Inflammation ; Inulin ; Obesity ; Pectin ; Short-chain Fatty Acids; Chain Fatty-acids; Adipose-tissue; Gut Microbiota; Animal-models; Antiinflammatory Properties; Fecal Water; Obesity; Expression; Genes; Infiltration
Sprache englisch
Veröffentlichungsjahr 2025
HGF-Berichtsjahr 2025
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Zeitschrift Scientific Reports
Quellenangaben Band: 15, Heft: 1, Seiten: , Artikelnummer: 8381 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
POF Topic(s) 30201 - Metabolic Health
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-506501-001
Förderungen German Federal Ministry of Research and Education (Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD) Halle-Jena-Leipzig)
Projekt DEAL
DOI 10.1038/s41598-025-92420-y
WOS ID 001442602500032
Scopus ID 105000080734
PubMed ID 40069546
Erfassungsdatum 2025-05-07
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