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Nakatani, T.

Dynamics of replication timing during mammalian development.

Trends Genet. 41, 568-576 (2025)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Recent developments in low-input genomics techniques have greatly advanced the analysis of the order in which DNA is replicated in the genome - that is, replication timing (RT) - and its interrelationships with other processes. RT correlates or anticorrelates with genomic-specific parameters such as gene expression, chromatin accessibility, histone modifications, and the 3D structure of the genome, but the significance of how they influence each other and how they relate to biological processes remains unclear. In this review I discuss the results of recent analyses of RT, the time at which it is remodeled and consolidated during embryogenesis, how it influences development and differentiation, and the regulatory mechanisms and factors involved.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter 3d Genome Organization ; Rif1 ; Embryonic Development ; Replication Stress ; Replication Timing; Dna-replication; Chromatin Architecture; Substitution Rates; Human Mutation; Repair; Genome; Heterochromatin; Transcription; Cells; Proteins
Sprache englisch
Veröffentlichungsjahr 2025
HGF-Berichtsjahr 2025
ISSN (print) / ISBN 0168-9479
Zeitschrift Trends in Genetics
Quellenangaben Band: 41, Heft: 7, Seiten: 568-576 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epigenetics and Stem Cells (IES)
POF Topic(s) 30204 - Cell Programming and Repair
Forschungsfeld(er) Stem Cell and Neuroscience
PSP-Element(e) G-506200-001
DOI 10.1016/j.tig.2025.01.010
WOS ID 001536424300006
Scopus ID 86000773685
PubMed ID 40082146
Erfassungsdatum 2025-05-07
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