PuSH - Publikationsserver des Helmholtz Zentrums München

Remus, S.L.* ; Brugetti, K.* ; Zimmer, V.A.* ; Hesse, N.* ; Reidler, P.L.* ; Giunta, R.E.* ; Schnabel, J.A. ; Demmer, W.*

Personalized joint replacement: Landmark-free morphometric analysis of distal radii.

J Funct. Morphol. Kinesiol. 10:71 (2025)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Background: Fractures of the distal radius are common, particularly among young men and elderly women, often leading to painful wrist arthritis, especially if the joint surface has been affected. Traditional treatments of the wrist, such as full or partial wrist fusion, limit movement, and common wrist prostheses have high complication rates. Regenerative medicine and 3D bioprinting offer the potential for personalized joint replacements. Methods: This study evaluates using the contralateral radius as a template for creating customized distal radius prostheses. Bilateral CT scans of healthy wrists were analyzed to assess the shape and symmetry of the distal radius using a landmark-free morphometric method. Instead of comparing defined landmarks, the entire surface of the radius is analyzed employing dense point- and deformation-based morphometry to detect subtle morphological differences, providing an unbiased and more accurate comparison of the overall deformations in the distal radii. Results: results show strong intraindividual symmetry in joint surfaces. Interindividual comparisons revealed significant morphological variations, particularly gender-specific differences. Conclusions: These findings support the use of the contralateral radius as a template for the replaced side. At the same time, the interindividual results endorse the approach of pursuing personalized prostheses as the optimal replacement for distal joint surfaces. The increasing improvement of 3D-printed prostheses promises new methods for better outcomes in distal radius arthrosis after intraarticular fractures. Further research into clinical applications and biocompatible 3D printing materials is recommended.
Altmetric
Weitere Metriken?
[➜Einloggen]
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter 3d-printed Prostheses ; Ct ; Anatomy Of The Wrist ; Distal Radius ; Hand Surgery ; Landmark-free Morphometry ; Mirror Symmetry; Articular Fractures; Arthroplasty; Fixation; Outcomes; End
ISSN (print) / ISBN 2411-5142
e-ISSN 2411-5142
Zeitschrift Journal of Functional Morphology and Kinesiology
Quellenangaben Band: 10, Heft: 1, Seiten: , Artikelnummer: 71 Supplement: ,
Verlag MDPI
Verlagsort Mdpi Ag, Grosspeteranlage 5, Ch-4052 Basel, Switzerland
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Machine Learning in Biomed Imaging (IML)