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A defect of CD16-positive monocytes can occur without disease.
Immunobiology 218, 169-174 (2013)
The CD16-positive monocytes have been first described in 1988 but to date no selective defect in the number of these cells in blood has been reported. We now describe a family in which three of four siblings lack both CD16-positive monocyte subsets, i.e. the nonclassical and the intermediate monocytes. All three had CD16-positive monocytes of 2cells/μl or less as compared to 52±18cells/μl in healthy controls. The index case was affected by recurrent pleural effusion and infections and had evidence of an auto-inflammatory condition but no mutation of any of the relevant candidate genes. The other two siblings without CD16-positive monocytes were apparently healthy. There was no defect in serum M-CSF levels and no mutation in the M-CSF and M-CSFR genes. The data indicate that the absence of CD16-positive monocytes in blood does not lead to disease.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Monocyte subsets; CD16-positive monocytes; Human peripheral blood; Colony-stimulating Factor ; Human Peripheral-blood ; Cd14(+)cd16(+) Monocytes ; Sporadic Monocytopenia ; Autosomal-dominant ; Cd16(+) Monocytes ; Linkage Analysis ; Macrophage ; Expression ; Identification
ISSN (print) / ISBN
0171-2985
e-ISSN
1878-3279
Zeitschrift
Immunobiology : Experimental and Clinical
Quellenangaben
Band: 218,
Heft: 2,
Seiten: 169-174
Verlag
Urban & Fischer
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed