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Kocijancic, M.* ; Roche, J.* ; Peter, A. ; Hörber, S.

Evaluation of the sysmex CN-6000 coagulation analyzer for routine and specialized coagulation testing in a central laboratory.

Clin. Lab. 71, 493-501 (2025)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Background: The Sysmex CN-6000 is a fully automated high-throughput coagulation analyzer. The objective of this study was to evaluate the analytical performance of the analyzer for routine and special coagulation testing in a high-throughput central laboratory of a university hospital. Methods: The within- and between-day precision and accuracy of 29 coagulation parameters were evaluated on the Sysmex CN-6000 using commercially available quality control materials. Patient plasma samples were used to compare results of coagulation measurements between the Sysmex CN-6000 and the Atellica COAG 360, including plasma samples with visual interference. The sample throughputs of both analyzers were compared using plasma samples from healthy volunteers. Results: Within- and between-day coefficients of variation were acceptable for all assays tested on the Sysmex CN6000. High correlation and good agreement were observed when comparing coagulation results from the Sysmex CN-6000 and the Atellica COAG 360. Samples with visual interference showed comparable coagulation results between the two analyzers, with slightly better detection by the Sysmex CN-6000. The sample throughput per hour for analysis of a panel of five coagulation parameters was higher with the Sysmex CN-6000 compared to the Atellica COAG 360 (247 vs. 193 tests). Conclusions: The Sysmex CN-6000 demonstrated excellent analytical performance for a large number of coagulation parameters and has a high throughput capacity, ideal for the needs of a central laboratory with a high volume of routine and specialized coagulation testing. (Clin. Lab. 2025;71:493-501. DOI: 10.7754/Clin.Lab.2024.240922)
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter hemostasis; coagulation; core laboratory; throughput; HIL check; Hemostasis
Sprache englisch
Veröffentlichungsjahr 2025
HGF-Berichtsjahr 2025
ISSN (print) / ISBN 1433-6510
Zeitschrift Clinical Laboratory
Quellenangaben Band: 71, Heft: 3, Seiten: 493-501 Artikelnummer: , Supplement: ,
Verlag Clinical Laboratory Publ.
Verlagsort Mainz
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502400-001
DOI 10.7754/Clin.Lab.2024.240922
WOS ID 001447978800014
Erfassungsdatum 2025-05-09
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