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Burton, A. ; Torres-Padilla, M.E.

Epigenome dynamics in early mammalian embryogenesis.

Nat. Rev. Genet., DOI: 10.1038/s41576-025-00831-4 (2025)
Postprint DOI PMC
Open Access Green
During early embryonic development in mammals, the totipotency of the zygote - which is reprogrammed from the differentiated gametes - transitions to pluripotency by the blastocyst stage, coincident with the first cell fate decision. These changes in cellular potency are accompanied by large-scale alterations in the nucleus, including major transcriptional, epigenetic and architectural remodelling, and the establishment of the DNA replication programme. Advances in low-input genomics and loss-of-function methodologies tailored to the pre-implantation embryo now enable these processes to be studied at an unprecedented level of molecular detail in vivo. Such studies have provided new insights into the genome-wide landscape of epigenetic reprogramming and chromatin dynamics during this fundamental period of pre-implantation development.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Zygotic Genome Activation; Cell Nuclear Transfer; To-embryo Transition; Novo Dna Methylation; Gene-expression; Mouse Embryos; Constitutive Heterochromatin; Chromatin Architecture; Rna Modifications; Transcription
ISSN (print) / ISBN 1471-0056
e-ISSN 1471-0064
Zeitschrift Nature Reviews - Genetics
Verlag Nature Publishing Group
Verlagsort Heidelberger Platz 3, Berlin, 14197, Germany
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epigenetics and Stem Cells (IES)
Förderungen National Institutes of Health 4DN programme
German Research Council
Helmholtz Association