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A prebiotic dietary pilot intervention restores faecal metabolites and may be neuroprotective in Parkinson's Disease.
npj Parkinsons Dis. 11:66 (2025)
Current treatment of Parkinson's Disease (PD) remains symptomatic, and disease-modifying approaches are urgently required. A promising approach is to modify intestinal microbiota and key metabolites of bacterial fermentation: short-chain fatty acids (SCFA), which are decreased in PD. A prospective, controlled pilot study (DRKS00034528) was conducted on 11 couples (PD patient plus healthy spouse as control (CO)). Participants followed a 4-week diet rich in dietary fibre, including intake of the prebiotic Lactulose. Gut metagenomes, faecal and urinary metabolites, and clinical characteristics were assessed. The dietary intervention significantly augmented faecal SCFA and increased Bifidobacteria spp., reducing PD-related gastrointestinal symptoms. The pre-existing bacterial dysbiosis in PD (depletion of Blautia, Dorea, Erysipelatoclostridium) persisted. Bacterial metabolite composition in faeces and urine positively changed with the intervention: Brain-relevant gut metabolic functions involved in neuroprotective and antioxidant pathways, including S-adenosyl methionine, glutathione, and inositol, improved in PD. These promising results warrant further investigation in larger cohorts.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Chain Fatty-acids; Intestinal Microbiota; Butyrate; Activation; Lactulose; Urine; Fiber; Model; Risk
ISSN (print) / ISBN
2373-8057
e-ISSN
2373-8057
Zeitschrift
npj Parkinson's Disease
Quellenangaben
Band: 11,
Heft: 1,
Artikelnummer: 66
Verlag
Springer
Verlagsort
Heidelberger Platz 3, Berlin, 14197, Germany
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Förderungen
BBSRC Institute Strategic Programme (ISP) Food Microbiome and Health
ISP Decoding Biodiversity
Cellular Genomics Cellular Genomics
Local grant (FEMHabil) at the medical faculty of the University Hospital Bonn
European Research Council H2020 StG
Hilde-Ulrichs-Foundation
ISP Decoding Biodiversity
Cellular Genomics Cellular Genomics
Local grant (FEMHabil) at the medical faculty of the University Hospital Bonn
European Research Council H2020 StG
Hilde-Ulrichs-Foundation