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Carli, G.* ; Dortmond, A.* ; Janzen, A.* ; Sittig, E.* ; De Meyer, E.* ; Leenders, K.L.* ; Oertel, W.H. ; Meles, S.K.*

Parkinson's Disease-Related pattern in isolated REM sleep behaviour disorder as a prodromal progression marker: 8-Year Follow-Up changes assessed at three time points.

Eur. J. Nucl. Med. Mol. Imaging, DOI: 10.1007/s00259-025-07260-9 (2025)
Postprint DOI PMC
Open Access Green
BACKGROUND: Isolated REM sleep behavior disorder (iRBD) is a prodromal stage of alpha-synucleinopathies. Biomarkers are crucial for predicting and monitoring its progression, warranting long-term neuroimaging studies. While the Parkinson's Disease Related Pattern (PDRP) from 18F-FDG PET is a recognized Parkinson's Disease (PD) biomarker, its role in tracking progression in prodromal PD remains unclear. OBJECTIVE: To explore PDRP expression across three time points using 18F-FDG PET over an 8-year follow-up in iRBD. METHODS: Thirteen iRBD subjects underwent 18F-FDG PET brain scans at baseline (BL), follow-up 1 (FU1, 4 years), and follow-up 2 (FU2, 8 years). Among them, four developed PD, one Dementia with Lewy Bodies (DLB), three showed subthreshold parkinsonism, and five showed no progression. PDRP z-scores were analyzed within and between groups (converters vs. non-converters) using a two-way repeated measures ANOVA. Similar analyses were conducted for motor scores (Unified Parkinson's Disease Rating Scale part three, UPDRS-III). RESULTS: There was a significant main effect of group (p = 0.011), time (p < 0.001), and a group*time interaction (p = 0.020), indicating that while PDRP z-scores increased over time in most iRBD subjects, the increase was more pronounced in converters (n = 5) than in non-converters (n = 8). Post-hoc tests revealed significantly higher PDRP z-scores in converters compared to non-converters at FU1 (p = 0.042) and FU2 (p = 0.024). For UPDRS-III scores we found significant effects of group (p = 0.011), time (p < 0.001), and their interaction (p = 0.0003). CONCLUSIONS: Repeated 18F-FDG PET scans may be useful to monitor prodromal disease progression and predict conversion in iRBD patients.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter 18f-fdg Pet ; Pdrp ; Brain Glucose Metabolism ; Disease Progression ; Irbd; Metabolic Network Activity; Criteria
ISSN (print) / ISBN 1619-7070
e-ISSN 1432-105X
Zeitschrift European Journal of Nuclear Medicine and Molecular Imaging
Verlag Springer
Verlagsort One New York Plaza, Suite 4600, New York, Ny, United States
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Neurogenomics (ING)
Förderungen Michael J. Fox Foundation (Edmond J. Safra Fellowship in Movement Disorders)
Charitable Hertie Foundation, Frankfurt/Main, Germany
German "ParkinsonFonds Deutschland"
Dutch "Stichting ParkinsonFonds"