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Freibothe, I.* ; Müller, T.D.

Inkretine als Grundlage der Adipositastherapie.

Incretins as the basis of obesity treatment.

Innere Med. 66, 461-466 (2025)
Verlagsversion DOI PMC
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Obesity represents an immense challenge for patients and physicians due to its numerous comorbidities and complications. For a long time, safe and effective pharmacological treatment remained wishful thinking. Bariatric surgery was considered the only option for sustained weight loss; however, with the advent of incretin-based treatment, initially introduced as a highly effective component of anti-diabetic treatment, research began to focus on the complex gastroenteropancreatic endocrine system, including central hunger and satiety regulation. This shift was driven by the discovery of a remarkable side effect: placebo-controlled weight reduction. Subsequent groundbreaking pharmacological developments based on long-acting peptides, the administration of which could be reduced from twice daily in earlier forms of treatment to once weekly, now enables significant weight reduction of over 20%, with a tolerable safety profile. This article provides an illustrative overview of the corresponding associations and highlights this milestone in obesity treatment.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Appetite Regulation ; Glucagon-like Peptide 1 (glp-1) ; Glucose-dependent Insulinotropic Polypeptide (gip) ; Obesity/drug Therapy ; Weight Loss; Appetite
Sprache deutsch
Veröffentlichungsjahr 2025
HGF-Berichtsjahr 2025
ISSN (print) / ISBN 2731-7080
e-ISSN 2731-7099
Zeitschrift Innere Medizin
Quellenangaben Band: 66, Heft: 5, Seiten: 461-466 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort Heidelbergerplatz 3, Berlin, Germany
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-501900-221
DOI 10.1007/s00108-025-01893-6
WOS ID 001464600300001
Scopus ID 105002290744
PubMed ID 40210769
Erfassungsdatum 2025-05-10
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