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Mendelian randomization study highlights the role of hematological traits on Type-2 diabetes mellitus in African ancestry individuals.
Front. Pharmacol. 16:1436972 (2025)
INTRODUCTION: Observational studies have identified associations between hematological traits and type-2 diabetes mellitus (T2D). However, it is difficult to infer causal effects due to the potential of confounding. Our study utilizes the Mendelian randomization (MR) approach to address the above limitation and investigate the causal effect of hematological traits such as white blood cell (WBC), platelets (PLT), and red blood cell (RBC) on T2D in individuals of African ancestry. METHODS: The participating cohorts included participants of African ancestry in the Blood Cell consortium and the Million Veteran Program dataset. Using GWAS summary statistics, we applied a univariable and multivariable Two-sample MR to estimate the causal relationship between hematological traits and T2D. RESULTS: In the main IVW MR estimates, genetically predicted levels of mean corpuscular hemoglobin concentration (MCHC), mean corpuscular hemoglobin (MCH), and mean corpuscular volume (MCV) were associated with decreased risk of T2D. We also observed a decreased risk of T2D with genetically predicted total WBC count and neutrophil count (NEU), for the WBC traits. The multivariable analysis further supported the direct associations of genetically predicted MCH, MCHC, and MCV levels with a decreased risk of T2D. For the European ancestry, a similar pattern of association was observed for MCH and MCV. DISCUSSION: These findings indicate that hematological traits may differentially play a role in the development of T2D and be affected by T2D. However, further research is needed to validate and explore the biological pathways and mechanisms involved in these associations.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Africa ; Hematological Traits ; Type-2 Diabetes ; Blood Cell Traits ; Mendelian Randomization; Atherosclerosis Risk; Inflammation; Health; Cells; Infection; Anemia; Level; Count
ISSN (print) / ISBN
1663-9812
e-ISSN
1663-9812
Zeitschrift
Frontiers in Pharmacology
Quellenangaben
Band: 16,
Artikelnummer: 1436972
Verlag
Frontiers
Verlagsort
Lausanne
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Translational Genomics (ITG)
Institute of Epidemiology (EPI)
Institute of Epidemiology (EPI)
Förderungen
German Academic Exchange Service (DAAD) in Germany
Foreign, Commonwealth and Development Office in the UK
Commonwealth Scholarship Commission
NIH NHGRI
Wellcome Trust
Africa Research Excellence Fund
National Institutes Of Health (OD), National Heart Lung and Blood Institute
Foreign, Commonwealth and Development Office in the UK
Commonwealth Scholarship Commission
NIH NHGRI
Wellcome Trust
Africa Research Excellence Fund
National Institutes Of Health (OD), National Heart Lung and Blood Institute