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Arrigo, A.* ; Cremona, O.* ; Aragona, E.* ; Casoni, F.* ; Consalez, G.* ; Dogru, R.M.* ; Hauck, S.M. ; Antropoli, A.* ; Bianco, L.* ; Parodi, M.B.* ; Bandello, F.* ; Grosche, A.*

Müller cells trophism and pathology as the next therapeutic targets for retinal diseases.

Prog. Retinal Eye Res. 106:101357 (2025)
Verlagsversion DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Müller cells are a crucial retinal cell type involved in multiple regulatory processes and functions that are essential for retinal health and functionality. Acting as structural and functional support for retinal neurons and photoreceptors, Müller cells produce growth factors, regulate ion and fluid homeostasis, and facilitate neuronal signaling. They play a pivotal role in retinal morphogenesis and cell differentiation, significantly contributing to macular development. Due to their radial morphology and unique cytoskeletal organization, Müller cells act as optical fibers, efficiently channeling photons directly to the photoreceptors. In response to retinal damage, Müller cells undergo specific gene expression and functional changes that serve as a first line of defense for neurons, but can also lead to unwarranted cell dysfunction, contributing to cell death and neurodegeneration. In some species, Müller cells can reactivate their developmental program, promoting retinal regeneration and plasticity-a remarkable ability that holds promising therapeutic potential if harnessed in mammals. The crucial and multifaceted roles of Müller cells-that we propose to collectively call "Müller cells trophism"-highlight the necessity of maintaining their functionality. Dysfunction of Müller cells, termed "Müller cells pathology," has been associated with a plethora of retinal diseases, including age-related macular degeneration, diabetic retinopathy, vitreomacular disorders, macular telangiectasia, and inherited retinal dystrophies. In this review, we outline how even subtle disruptions in Müller cells trophism can drive the pathological cascade of Müller cells pathology, emphasizing the need for targeted therapies to preserve retinal health and prevent disease progression.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Müller Cells ; Age-related Macular Degeneration ; Diabetic Retinopathy ; Inherited Retinal Dystrophies ; Macular Teleangectasia ; Pathology ; Trophism ; Vitreomacular Disorders; Muller Glial-cells; Endothelial Growth-factor; Internal Limiting Membrane; Osmotic Volume Regulation; Tight Junction Trafficking; Cystoid Macular Edema; Neurotrophic Factor; High Glucose; Differential Expression; Pigment Epithelium
ISSN (print) / ISBN 1350-9462
e-ISSN 1873-1635
Zeitschrift Progress in retinal and eye research
Quellenangaben Band: 106, Heft: , Seiten: , Artikelnummer: 101357 Supplement: ,
Verlag Elsevier
Verlagsort Oxford [u.a.]
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) CF Metabolomics & Proteomics (CF-MPC)