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Götz, M. ; Torres-Padilla, M.E.

Stem cells as role models for reprogramming and repair.

Science 388:eadp2959 (2025)
DOI PMC
Closed: Verlagsversion online verfügbar 05/2026
Stem cells are a promising source for cellular therapies across many diseases and tissues. Their inherent ability to differentiate into other cell types has been the focus of investigation over decades. This ability is currently being exploited for therapies using strategies to repair or replace damaged tissues and cells or to alleviate immune rejection. Exploring stem cell function has enabled direct reprogramming approaches, for example, through the production of induced pluripotent stem cells and the generation of tissue-specific stem cells. Understanding stem cell function has emerged as an important strategy for repopulating stem cell pools or generating differentiated cells for therapy. Here, we review general principles of mammalian stem cell biology and cellular reprogramming approaches and their use for current and future therapeutic purposes.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Neural Stem; Mouse Fibroblasts; Direct Conversion; Adult Brain; Neurons; Liver; Regeneration; Identification; Quiescence; Astrocytes
Sprache englisch
Veröffentlichungsjahr 2025
HGF-Berichtsjahr 2025
ISSN (print) / ISBN 0036-8075
e-ISSN 1095-9203
Zeitschrift Science
Quellenangaben Band: 388, Heft: 6746, Seiten: , Artikelnummer: eadp2959 Supplement: ,
Verlag American Association for the Advancement of Science (AAAS)
Verlagsort 1200 New York Ave, Nw, Washington, Dc 20005 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epigenetics and Stem Cells (IES)
Institute of Stem Cell Research (ISF)
POF Topic(s) 30204 - Cell Programming and Repair
Forschungsfeld(er) Stem Cell and Neuroscience
PSP-Element(e) G-506200-001
G-500800-001
Förderungen German Research Foundation
German Research Foundation (SyNergy project)
European Union (NSC Reconstruct project)
Helmholtz Association
DOI 10.1126/science.adp2959
WOS ID 001488571700023
Scopus ID 105004481569
PubMed ID 40310926
Erfassungsdatum 2025-05-05
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