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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Soluble alpha klotho - impact of biological variables and reference intervals for adults.
Eur. J. Endocrinol. 192, 631-640 (2025)
OBJECTIVE: Concentrations of soluble alpha klotho (sαKL) are higher in active acromegaly compared to healthy controls. However, reference intervals based on large population-based samples are lacking, and the impact of many biological variables is unclear. DESIGN: Cross-sectional study. METHODS: We measured sαKL concentrations in samples from an adult population (20-89 years, 435 males, 455 females). Associations with sex, age, body mass index, waist-hip-ratio, estimated glomerular filtration rate (eGFR), IGF-I and IGFBP 3, glucose-, lipid-, calcium- and liver-metabolism, fasting, and estrogen status were analyzed. Reference intervals were calculated using LMS quantile regression with a Box-Cox transformation to normality. We also analyzed sαKL in patients with non-functioning pituitary adenoma (NFPA, n=18) and prolactinoma (n=65). RESULTS: Across all ages, sαKL concentrations (pg/mL, median (IQR)) were slightly, but significantly higher in females compared to males (678 (537-859) vs. 651 (537-812), p=0.01), suggesting an impact of estrogens. SαKL exhibited a weak negative correlation with age, and positive correlations with eGFR and IGF-I (p<0.001 for both). Correlations to other biological factors including glucose, liver and calcium metabolism and duration of fasting were negligible (p>0.05 for all). Compared to sαKL, IGF-I more often was correlated significantly to other biological variables. SαKL was not different in patients with NFPA, but slightly higher in patients with prolactinoma (p<0.05). CONCLUSION: Our findings suggest sαKL is a stable GH-sensitive biomarker, that may be less impacted by biological variables compared to IGF-I and IGFBP 3. Our reference intervals will facilitate the potential use of sαKL in GH-related diseases.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Acromegaly ; Biomarker ; Growth Hormone ; Population-based Study
ISSN (print) / ISBN
0804-4643
e-ISSN
1479-683X
Zeitschrift
European Journal of Endocrinology
Quellenangaben
Band: 192,
Heft: 5,
Seiten: 631-640
Verlag
BioScientifica
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Epidemiology (EPI)