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Schormair, B.

Genetics of restless legs syndrome: Insights from genome-wide association studies.

Sleep Med. Clin. 20, 193-202 (2025)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Genome-wide association studies (GWAS) of common and low-frequency variants have discovered 164 genetic risk loci for restless legs syndrome (RLS) in adult populations of European ancestry. Sex-specific GWAS meta-analyses revealed largely overlapping genetic risk profiles for women and men and are in line with a nongenetic risk factor driving the higher prevalence seen in women. Genetic investigations of pediatric RLS are limited, but the likely inclusion of early-onset cases in GWAS of adult populations and the similar phenotypic presentation of both forms suggest that genetic risk variants identified in adult populations transfer to pediatric RLS.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Gwas ; Genetic Architecture ; Genome-wide Association Study ; Meta-analysis ; Polygenic Risk Score ; Rls ; Restless Legs Syndrome; Diagnostic-criteria; Childhood-onset; Complex; Risk; Age; Locus; Polygenicity; Heritability; Architecture; Variants
Sprache englisch
Veröffentlichungsjahr 2025
HGF-Berichtsjahr 2025
ISSN (print) / ISBN 1556-407X
e-ISSN 1556-4088
Zeitschrift Sleep Medicine Clinics
Quellenangaben Band: 20, Heft: 2, Seiten: 193-202 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort 525 B Street, Ste 1900, San Diego, Ca 92101-4495 Usa
Institut(e) Institute of Neurogenomics (ING)
POF Topic(s) 30205 - Bioengineering and Digital Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-503200-001
DOI 10.1016/j.jsmc.2025.02.008
WOS ID 001493772500005
PubMed ID 40348531
Erfassungsdatum 2025-05-12
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