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Merino, F.L. ; Götz, M.

The role of moonlighting proteins in neurogenesis.

Curr. Opin. Neurobiol. 93:103047 (2025)
Verlagsversion DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
The complexity of the mammalian brain must arise from a comparably small number of genes. Proteins with moonlighting functions, i.e. entirely different functions in different compartments or cell types, contribute to multiply functional diversity. Here we review examples of such proteins with moonlighting functions during neurogenesis and in neuronal maturation. These range from cytoskeletal proteins acting as transcriptional regulators or synaptic proteins or exon junction proteins binding to and regulating the cytoskeleton to immediate early gene transcription factors regulating lipid metabolism in the endoplasmic reticulum. We further discuss how proteins with such moonlighting functions contribute to the heterogeneity of organelles shaping cell-type diversity in the brain.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
ISSN (print) / ISBN 0959-4388
e-ISSN 1873-6882
Zeitschrift Current Opinion in Neurobiology
Quellenangaben Band: 93, Heft: , Seiten: , Artikelnummer: 103047 Supplement: ,
Verlag Elsevier
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Stem Cell Research (ISF)