PuSH - Publikationsserver des Helmholtz Zentrums München

Pott, H.* ; Weckler, B.* ; Heier, M. ; Peters, A. ; Vogelmeier, C.* ; Karrasch, S.* ; Schmeck, B.*

Chronic cough and expectoration do not predict development of airflow obstruction, but FEV1 decline: Results from the KORA-study.

Pneumologie 79, S23 - S24 (2025)
DOI
Background: Chronic Bronchitis has been proposed by GOLD as a phenotype of pre-COPD. Besides, chronic bronchitis has consistently been linked to increased decline in FEV1. Recently, an analysis of the Copenhagen Health Study linked chronic bronchitis to development of COPD. Therefore, we investigated associations of chronic bronchitis with FEV1 decline and development of COPD in the German population-based cohort KORA. Methods: 2255 individuals from KORA were analysed for signs of chronic cough and/or expectoration. Patients came from two groups, one with n=1320, aged 41 – 62 years, the other with n=935, aged 65 – 90 years. Spirometry data were analyzed with healthy lung function status defined as FEV1/FVC>0.7 and>10th percentile, as well as FEV1 and FVC% pred.>80%, and COPD defined as FEV1/FVC<0.7 and<lower limit of normal. Chronic bronchitis was assessed as patient-reported presence of chronic cough with expectoration for at least three months per year. Patients were followed over a period of 3.5 – 7 years. Results: In the higher age group, chronic cough and expectoration was associated with an increased risk for high yearly FEV1 decline (> 100 ml, OR 2.3 [1.42 – 3.72], p<0.001), but not a spirometry result consistent with development of COPD. Simultaneously, no such association was found in younger individuals. Generally, most patients with chronic cough or expectoration did not display airflow obstruction, PRISM or early airflow limitation, defined as FEV1/FVC>0.7 and<10th percentile or FEV1/FVC<0.7 and in range of 5th to 10th percentile. Spirometry values of patients with chronic cough and/or expectoration displayed no clustering pattern when compared to COPD or at-risk for COPD subgroups. Conclusion: In a population-based cohort of middle-aged and older individuals, chronic cough and/or expectoration were in the majority associated with normal lung function status. Chronic bronchitis symptoms did not predict development of COPD during follow-up. However, presence of cough/and or bronchitis was significantly associated with increased FEV1 decline in elder individuals.
Altmetric
Weitere Metriken?
[➜Einloggen]
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Meeting abstract
Korrespondenzautor
Schlagwörter Chronic Cough
ISSN (print) / ISBN 0934-8387
e-ISSN 1438-8790
Zeitschrift Pneumologie
Quellenangaben Band: 79, Heft: S 01, Seiten: S23 - S24 Artikelnummer: , Supplement: ,
Verlag Thieme
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)