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Nabi, N.* ; Nisa, M.U.* ; Khan, M.S.* ; Gillani, S.Q.

Role of signaling pathways regulating cell cycle progression in cancer.

In: Cell Signaling Pathways and Their Therapeutic Implication in Cancers. 2025. 357-394 (Cell Signaling Pathways and Their Therapeutic Implication in Cancers)
DOI
Every cell arises from the preexisting cell as it undergoes cell division. All the cells that exist today are believed to have originated from a common ancestral cell that lived billions of years ago. Through this vast expanse of time life existed and survived by relaying genetic information through the process of cellular reproduction. In the cell cycle, a cell undergoes the cycle of events thereby replicating its contents and segregating them accurately among the daughter cells so that they receive all the information and machineries to carry forward and repeat the same process. Cell duplication is a central and principal mechanism required for the progress and function of life. The core doctrine of the cell cycle is that its progression is governed by the activity of a specific group of serine/threonine (S/T) kinases called CDKs in conjunction with their partner proteins, the cyclins. These proteins ensure the proper coordination of the main three cell cycle events that follow the sequence: chromosomal duplication, mitotic entry, chromosomal segregation, and finally cytokinesis. The succession of these events is regulated by an intricate web of signaling conduits that govern the function of CDKs and cyclins. There are numerous feedback loops, both negative and positive, that maintain the order of proceedings in the cell cycle. Also, there are several signaling mechanisms in place to safeguard genomic accuracy. These signaling webs allow the cells to divide only after certifying that DNA lesions or breaks have been repaired and that there is proper separation and distribution of chromosomes into daughter cells. Any deregulation in these pathways manifests itself in the form of serious human diseases like cancers or hereditary disorders like developmental malformations, autoimmune diseases, growth defects, etc. The abnormal expression or functioning of any protein member of these regulatory pathways leads to an abnormal cell cycle which gives rise to tumor cells. These cells have the properties of being antiapoptotic, metastatic, invasiveness, and drug-resistant. Therefore, these pathways are the central targets of anticancer therapeutics. This chapter explains the numerous facets of the cell cycle and the various signaling channels that control it. We also discuss the potential utilization of cell cycle regulatory networks as therapeutic targets for cancer.
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Publikationstyp Artikel: Sammelbandbeitrag/Buchkapitel
Korrespondenzautor
Schlagwörter Cancer ; Cell Cycle ; Chemotherapeutic Inhibitors ; Cyclins ; Mapk ; Mitosis ; Pi3k ; Signaling
ISSN (print) / ISBN [9789819627639, 9789819627622]
Bandtitel Cell Signaling Pathways and Their Therapeutic Implication in Cancers
Quellenangaben Band: , Heft: , Seiten: 357-394 Artikelnummer: , Supplement: ,
Nichtpatentliteratur Publikationen
Institut(e) Institute of Diabetes and Cancer (IDC)