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De Backer, J.F.* ; Karges, T.* ; Papst, J.* ; Pınar, Z.N.* ; Coman, C.* ; Ahrends, R.* ; Xu, Y. ; García-Cáceres, C. ; Grunwald Kadow, I.C.*

Adenosine signaling in glia modulates metabolic state-dependent behavior in Drosophila.

Cell Rep. 44:115765 (2025)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
An animal's metabolic state strongly influences its behavior. Hungry animals prioritize food-seeking and feeding behaviors, while sated animals suppress these behaviors to engage in other activities. Additionally, neuronal activity and synaptic transmission are among the most energy-expensive processes. However, neurons do not uptake nutrients from the circulation. Instead, glia fulfill this highly evolutionarily conserved function in addition to modulating neuronal activity and behavior. However, how different glia subtypes sense metabolic state and modulate behavior is incompletely understood. Here, we unravel two types of glia-mediated modulation of metabolic-state-dependent behavior. In food-deprived flies, astrocyte-like and perineurial glia promote foraging and feeding, respectively, while cortex glia suppress these behaviors. We further show that adenosine and adenosine receptors modulate intracellular calcium levels in these glia subtypes, which ultimately controls behavior. This study reveals a mechanism of how different glia subtypes sense an animal's metabolic state and modulate its behavior accordingly.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Cp: Metabolism ; Drosophila ; Adenosine ; Chemosensation ; Feeding ; Glia ; Metabolic-state-dependent Behavior ; Metabolism ; Neural Circuits; Blood-brain-barrier; In-vivo; Astrocytes; Deaminase; Receptor; Neurons; System; Cells; Circuit; Valence
ISSN (print) / ISBN 2211-1247
e-ISSN 2211-1247
Zeitschrift Cell Reports
Quellenangaben Band: 44, Heft: 6, Seiten: , Artikelnummer: 115765 Supplement: ,
Verlag Cell Press
Verlagsort 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)
Förderungen
Munich Cluster for Systems Neurology
Helmholtz Excellence Network
German Research Foundation (DFG)
State of North Rhine-Westphalia
German Research Foundation