PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Standl, M. ; Budu-Aggrey, A.* ; Johnston, L.J.* ; Elias, M.S.* ; Arshad, S.H.* ; Bager, P.* ; Bataille, V.* ; Blakeway, H.* ; Bønnelykke, K.* ; Boomsma, D.* ; Brumpton, B.M.* ; Bustamante Pineda, M.* ; Campbell, A.* ; Curtin, J.A.* ; Eliasen, A.U.* ; Fadista, J.P.S.* ; Feenstra, B.* ; Gerner, T.* ; Medina-Gomez, C.* ; Grosche, S.* ; Gutzkow, K.B.* ; Halling, A.S.* ; Hayward, C.* ; Henderson, J.* ; Herrera-Luis, E.* ; Holloway, J.W.* ; Hottenga, J.* ; O'B Hourihane, J.* ; Hu, C.* ; Hveem, K.* ; Irizar, A.* ; Jacquemi, B.* ; Jessen, L.E.* ; Kress, S.* ; Kurukulaaratchy, R.J.* ; Lau, S.* ; Llop, S.* ; Løset, M.* ; Marenholz, I.* ; Mason, D.* ; McCartney, D.L.* ; Melbye, M.* ; Melén, E.* ; Minica, C.C.* ; Murray, C.S.* ; Nijsten, T.* ; Pardo, L.M.* ; Pasmans, S.G.M.A.* ; Pennell, C.E.* ; Rinnov, M.R.* ; Santorelli, G.* ; Schikowski, T.* ; Sheehan, D.* ; Simpson, A.* ; Söderhäll, C.* ; Thomas, L.F.* ; Thyssen, J.P.* ; Torrent, M.* ; van Beijsterveldt, T.* ; Visconti, A.* ; Vonk, J.M.* ; Wang, C.A.* ; Xu, C.J.* ; Ziyab, A.H.* ; Custovic, A.* ; Di Meglio, P.* ; Duijts, L.* ; Flohr, C.* ; Irvine, A.D.* ; Koppelman, G.H.* ; Lee, Y.A.* ; Reynolds, N.J.* ; Smith, C.* ; Langan, S.M.* ; Paternoster, L.* ; Brown, S.J.*

Gene-environment interaction affects risk of atopic eczema: Population and in vitro studies.

Allergy 80, 2201-2212 (2025)
Verlagsversion Forschungsdaten DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
BACKGROUND: Multiple environmental and genetic factors play a role in the pathogenesis of atopic eczema (AE). We aimed to investigate gene-environment interactions (G × E) to improve understanding of the pathophysiology. METHODS: We analysed data from 16 European studies to test for interaction between the 24 most significant AE-associated loci identified from genome-wide association studies and 18 early-life environmental factors. We tested for replication using a further 10 studies and in vitro modeling to independently assess findings. RESULTS: The discovery analysis (including 25,339 individuals) showed suggestive evidence for interaction (p < 0.05) between seven environmental factors (antibiotic use, cat ownership, dog ownership, breastfeeding, elder sibling, smoking and washing practices) and at least one established variant for AE, 14 interactions in total. In the replication analysis (254,532 individuals) dog exposure × rs10214237 (on chromosome 5p13.2 near IL7R) was nominally significant (ORinteraction = 0.91 [0.83-0.99] p = 0.025), with a risk effect of the T allele observed only in those not exposed to dogs. A similar interaction with rs10214237 was observed for siblings in the discovery analysis (ORinteraction = 0.84 [0.75-0.94] p = 0.003), but replication analysis was under-powered (ORinteraction = 1.09 [0.82-1.46]). rs10214237 homozygous risk genotype is associated with lower IL-7R expression in human keratinocytes, and dog exposure modelled in vitro showed a differential response according to rs10214237 genotype. CONCLUSION: Interaction analysis and functional assessment provide preliminary evidence that early-life dog exposure may modify the genetic effect of rs10214237 on AE via IL7R, supporting observational epidemiology showing a protective effect for dog ownership. The lack of evidence for other G × E studied here implies only weak effects are likely to occur.
Impact Factor
Scopus SNIP
Altmetric
12.000
0.000
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Atopic Eczema ; Dog ; Environment ; Gene ; Interaction; Genome-wide Association; Dermatitis; Mutations; Allergy; Asthma
Sprache englisch
Veröffentlichungsjahr 2025
HGF-Berichtsjahr 2025
ISSN (print) / ISBN 0105-4538
e-ISSN 1398-9995
Zeitschrift Allergy
Quellenangaben Band: 80, Heft: 8, Seiten: 2201-2212 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort 111 River St, Hoboken 07030-5774, Nj Usa
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504000-008
Förderungen Netherlands Ministry of Health, Welfare, and Sport
Wellcome Trust
German Federal Ministry of Education and Research
Innovative Medicines Initiative
European Research Council
National Institute for Health and Care Research
BMA James Trust
The JP Moulton Charitable Foundation
The North West Lung Centre Charity
Netherlands Organization for Health Research and Development
Ministerio de Ciencia e Innovación
European Science Foundation
Asthma and Lung UK
Netherlands Organization for Scientific Research
Lung Foundation Netherlands
Netherlands Ministry of Spatial Planning, Housing, and the Environment
Medical Research Council
DOI 10.1111/all.16605
WOS ID 001556362500015
WOS ID 001501683600001
Scopus ID 105007759291
PubMed ID 40462597
Erfassungsdatum 2025-06-05
[➜Korrektur melden]