Zografou, I.* ; Doukelis, P.* ; Koufakis, T.* ; Kotzakioulafi, E.* ; Evripidou, P.* ; Kontoninas, Z.* ; Savopoulos, C.* ; Doumas, M.* ; Didangelos, T.* ; Kantartzis, K.
High diagnostic performance of the indicator plaster neuropad for the detection of established diabetic autonomic neuropathy.
Diabetol. 6:55 (2025)
Aim: The aim of this study was to evaluate the specificity, sensitivity and accuracy of the Indicator Plaster Neuropad in detecting established Diabetic Autonomic Neuropathy (DAN). Methods: We studied 180 patients with Diabetes Mellitus (DM, mean age 49.5 ± 16 years, 82 with DM type 1). All patients underwent the following Cardiovascular Reflex Tests (CARTs): R-R variation during deep breathing (Mean Circular Resultant (MCR) and standard deviation (SD)), Valsalva maneuver, R-R variability after a rapid change from lying to standing position and postural hypotension. The presence of DAN was established if ≥2 CARTs were abnormal. According to the result the patients were divided into two groups, one with DAN and one without DAN. Assessment with Neuropad was performed also in all patients. Results: Abnormal perspiration with Neuropad (uncompleted or no change in color) was detected in 94 patients. Established DAN was detected in 85 patients. The sensitivity, specificity and accuracy of Neuropad for the diagnosis of established DAN were 87.1%, 78.9% and 82.8%, respectively and area under the curve was 0.846 and 95% CI (0.787, 0.905). Conclusions: Neuropad has high sensitivity, specificity, and accuracy in detecting established DAN, as defined by ≥2 abnormal CARTs.
Impact Factor
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Times Cited
Scopus
Cited By
Altmetric
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Typ der Hochschulschrift
Herausgeber
Schlagwörter
Accuracy ; Diabetic Autonomic Neuropathy ; Diagnostic Tests ; Neuropad ; Sensitivity; Peripheral Neuropathy; Management; Impact
Keywords plus
Sprache
englisch
Veröffentlichungsjahr
2025
Prepublished im Jahr
0
HGF-Berichtsjahr
2025
ISSN (print) / ISBN
2673-4540
e-ISSN
ISBN
Bandtitel
Konferenztitel
Konferzenzdatum
Konferenzort
Konferenzband
Quellenangaben
Band: 6,
Heft: 6,
Seiten: ,
Artikelnummer: 55
Supplement: ,
Reihe
Verlag
MDPI
Verlagsort
Mdpi Ag, Grosspeteranlage 5, Ch-4052 Basel, Switzerland
Tag d. mündl. Prüfung
0000-00-00
Betreuer
Gutachter
Prüfer
Topic
Hochschule
Hochschulort
Fakultät
Veröffentlichungsdatum
0000-00-00
Anmeldedatum
0000-00-00
Anmelder/Inhaber
weitere Inhaber
Anmeldeland
Priorität
Begutachtungsstatus
Peer reviewed
POF Topic(s)
90000 - German Center for Diabetes Research
Forschungsfeld(er)
Helmholtz Diabetes Center
PSP-Element(e)
G-502400-001
Förderungen
Pharma Unimedis, Greece (Pharma Unimedis, Athens, Greece)
Copyright
Erfassungsdatum
2025-07-08