PuSH - Publikationsserver des Helmholtz Zentrums München: Human adipose tissue gene expression signatures indicate an inflammatory response and retinoic receptor activation under persistent organic pollutants exposure.

Informationen

Hinweise zu Qualitätskriterien von Zeitschriften

Open-Access-Richtlinie der Helmholtz-Gemeinschaft 2016

CC Licencences

Metriken für Publikationen

Navigation

Startseite

English

Recherche

Erweiterte Suche

Durchblättern nach ...

... HMGU-Autoren/Konsortien

... Organisationsstruktur

... Zeitschriften

... Publikationstypen

... Forschungsdaten

... Arbeitsgruppen

... Erscheinungsjahr

Publikationen im Überblick

Statistik

HGF Fortschrittsbericht

OA Publikationen

Eintragen

Neue Publikation eintragen

Neue Publikation holen aus...

...EVA

Fehlende Publikation melden

Highlights

Suche

Hilfe & Kontakt

Ansprechpartner

Hilfe

Datenschutz

Helmholtz Open Science

Bibliometrische Indikatoren

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Hagemann, T. ; Rolle-Kampczyk, U.* ; Schubert, K.* ; Dietrich, A.* ; von Bergen, M.* ; Blüher, M. ; Hoffmann, A.

Human adipose tissue gene expression signatures indicate an inflammatory response and retinoic receptor activation under persistent organic pollutants exposure.

Environ. Adv. 21:100655 (2025)

Verlagsversion

Forschungsdaten

DOI

Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.

Abstract
Metriken
Zusatzinfos

Adipose tissue (AT) is subject to permanent accumulation of persistent organic pollutants (POP) due to their hydrophobic nature. Therefore, AT can be considered as interface between the body and an increasingly complex exposure to the chemical environment. As endocrinologically activate tissue, AT itself secretes adipokines regulating inflammation, insulin sensitivity and energy expenditure among others which are known to be dysfunctional in obesity. This study examined the impact of accumulated POPs 4,4-Diisoopropylbiphenyl (DIPB) and Ethyltetradecanoate (ETD) on human AT function. RNA-sequencing based gene expression analysis was conducted within the Leipzig Obesity Biobank (LOBB) between individuals (N = 43) with positive concentrations of DIPB and ETD in body fat against negative controls in subcutaneous (SAT) and visceral AT (VAT) in a sex-specific manner independent of their obesity status. Our study reveals sex- and AT-depot-specific gene expression profiles associated with immune responses, NF-κB signaling, and PPARγ pathways, highlighting POP interaction with immunological reactions in AT independent of obesity. Notably, our findings suggest altered retinoid acid receptor activity, which may influence AT browning. This research provides novel insights into the molecular mechanisms underlying the impact of POP exposure on human AT function. Importantly, our results indicate that POP exposure can contribute to AT dysfunction independently of obesity, suggesting that external environmental factors, such as POPs, should be considered as potential drivers of AT dysfunction in future obesity-related studies.

Impact Factor

Scopus SNIP

Altmetric

0.000

1.264