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Subochev, P.V.* ; Deán-Ben, X.L.* ; Chen, Z.* ; Prudnikov, M.B.* ; Vorobev, V.A.* ; Kurnikov, A.A.* ; Orlova, A.G.* ; Postnikova, A.S.* ; Kharitonov, A.V.* ; Proyavin, M.D.* ; Ovsyannikov, R.I.* ; Sanin, A.G.* ; Kirillin, M.Y.* ; Montero de Espinosa, F.* ; Turchin, I.V.* ; Razansky, D.

Ultrawideband high density polymer-based spherical array for real-time functional optoacoustic micro-angiography.

Light Sci. Appl. 14:239 (2025)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Owing to its unique ability to capture volumetric tomographic information with a single light flash, optoacoustic (OA) tomography has recently demonstrated ultrafast imaging speeds ultimately limited by the ultrasound time-of-flight. The method's scalability and the achievable spatial resolution are yet limited by the narrow bandwidth of piezo-composite arrays currently employed for OA signal detection. Here we report on the first implementation of high-density spherical array technology based on flexible polyvinylidene difluoride films featuring ultrawideband (0.3-40 MHz) sub mm2 area elements, thus enabling real-time multi-scale volumetric imaging with 22-35 µm spatial resolution, superior image fidelity and over an order of magnitude signal-to-noise enhancement compared to piezo-composite equivalents. We further demonstrate five-dimensional (spectroscopic, time-resolved, volumetric) imaging capabilities by visualizing fast stimulus-evoked cerebral oxygenation changes in mice and performing real-time functional angiography of deep human micro-vasculature. The new technology thus leverages the true potential of OA for quantitative high-resolution visualization of rapid bio-dynamics across scales.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Photoacoustic Tomography; Optical-properties; Parameters
ISSN (print) / ISBN 2047-7538
e-ISSN 2047-7538
Zeitschrift Light: Science & Applications
Quellenangaben Band: 14, Heft: 1, Seiten: , Artikelnummer: 239 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)
Förderungen Helmholtz Association
Russian Science Foundation
European Research Council
Swiss National Science Foundation