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Naik, T.* ; Verma, H.K. ; Mulkalwar, M.* ; Mishra, D.* ; Bhaskar, L.*

Comprehensive meta-analysis on the impact of the MDM2 SNP 309 T>G gene variant in leukemia susceptibility.

Curr. Pharm. Des., DOI: 10.2174/0113816128368759250527073556 (2025)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
INTRODUCTION: Genetic factors play a significant role in the development of leukemia. The overexpression of MDM2 is associated with the progression of certain leukemias. This meta-analysis investigates the relationship between the MDM2 SNP 309T>G and various forms of leukemia across global populations. METHODS: A comprehensive literature search was conducted to retrieve genotyping data from twenty casecontrol studies related to MDM2 SNP 309T>G polymorphism and leukemia. A random-effects model was used to calculate the pooled odds ratio (OR) and 95% confidence interval (95% CI) for the association analysis. MetaGenyo software was utilized to conduct statistical analyses in this meta-analysis. RESULTS: The findings indicate a significant association between MDM2 309 SNPT>G polymorphism and leukemia in Asian and Caucasian populations. Additionally, this polymorphism is associated with an increased risk of Acute Myeloid Leukemia (AML) and Chronic Myeloid Leukemia (CML), implying that MDM2 may play a role in the pathogenesis of these specific forms of leukemia. CONCLUSION: This meta-analysis suggests that MDM2 may represent a susceptibility gene for leukemia risk.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Aml ; Cml. ; Mdm2 309 Snp T>g ; Leukemia ; Meta-analysis ; Rs2279744; Single Nucleotide Polymorphism; Acute Lymphoblastic-leukemia; Acute Myeloid-leukemia; Codon 72; T309g Polymorphism; Risk; Association; Survival; Onset; Aml
ISSN (print) / ISBN 1381-6128
e-ISSN 1873-4286
Zeitschrift Current Pharmaceutical Design
Verlag Bentham Science Publishers
Verlagsort Executive Ste Y-2, Po Box 7917, Saif Zone, 1200 Br Sharjah, U Arab Emirates
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Lung Health and Immunity (LHI)