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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: The EUROSPAN project.
Circ. Cardiovasc. Genet. 2, 322-328 (2009)
BACKGROUND: We set out to identify common genetic determinants of the length of the RR and QT intervals in 2325 individuals from isolated European populations. METHODS AND RESULTS: We analyzed the heart rate at rest, measured as the RR interval, and the length of the corrected QT interval for association with 318 237 single-nucleotide polymorphisms. The RR interval was associated with common variants within GPR133, a G-protein-coupled receptor (rs885389, P=3.9 x 10(-8)). The QT interval was associated with the earlier reported NOS1AP gene (rs2880058, P=2.00 x 10(-10)) and with a region on chromosome 13 (rs2478333, P=4.34 x 10(-8)), which is 100 kb from the closest known transcript LOC730174 and has previously not been associated with the length of the QT interval. CONCLUSIONS: Our results suggested an association between the RR interval and GPR133 and confirmed an association between the QT interval and NOS1AP.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Genetics; Heart rate; Population
ISSN (print) / ISBN
1942-325X
e-ISSN
1942-3268
Zeitschrift
Circulation: Cardiovascular Genetics
Quellenangaben
Band: 2,
Heft: 4,
Seiten: 322-328
Verlag
Lippincott Williams & Wilkins
Verlagsort
Hagerstown, Md
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Human Genetics (IHG)