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Li, Q.* ; Ali, Z. ; Zakian, C. ; Di Pietro, M.* ; Honing, J.* ; O'Donovan, M.* ; Flisikowski, K.* ; Sarantos, V.* ; Pierre, G.* ; Gloriod, J.* ; Drexler, W.* ; Ntziachristos, V.

Tethered optoacoustic and optical coherence tomography capsule endoscopy for label-free assessment of Barrett's oesophageal neoplasia.

Nat. Bio. Eng., DOI: 10.1038/s41551-025-01462-0 (2025)
Verlagsversion Forschungsdaten DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Endoscopic detection of oesophageal cancer (EC) often occurs late in disease development, leading to high mortality rates. Improved technologies are urgently needed for earlier EC detection. Here we research an endoscopic ultra-broadband acoustic detection scheme and introduce a 360-degree hybrid optoacoustic and optical coherence endoscopy to enable interrogation of surface and subsurface precancerous and cancerous features at a three-dimensional micrometre scale. In the following pilot tissue investigation, the dual-modal imaging features are assessed for classifying different mucosal types in Barrett's oesophagus (BE)-a precursor of EC. We find that human lesions of different grades, such as metaplastic, dysplastic and cancerous mucosa, exhibit distinctly different imaging features that are unique to the hybrid modality. Based on these features, a classification system is developed and evaluated for identifying BE neoplasia. The results show accurate BE neoplasia detection due to the complementarity of the two imaging modalities. Therefore, this study highlights the ability of the new dual-modality feature set to improve the detection performance of any of the two modalities operating in stand-alone mode and enhance diagnostic accuracy.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Volumetric Laser Endomicroscopy; Squamous-cell Carcinoma; Blue-directed Biopsies; Intestinal Metaplasia; In-vivo; Dysplasia; Diagnosis; Surveillance; Management; Adenocarcinoma
ISSN (print) / ISBN 2157-846X
e-ISSN 2157-846X
Zeitschrift Nature biomedical engineering
Verlag Nature Publishing Group
Verlagsort London ; New York NY ; Tokyo
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)
Förderungen European Union
EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020)