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Superparamagnetic iron oxide nanoparticles conjugated to a grass pollen allergen and an optical probe.
Contrast Media Mol. Imaging 7, 435-439 (2012)
In this study we report the development of a bioconjugate between superparamagnetic iron oxide nanoparticles and Phl p5a (one of the major allergens from grass pollen). The bioconjugate also contains an optical probe (Alexa647) conjugated to the nanoparticle via biotinstreptavidin association. We show that this conjugate has a range of features that makes it a very promising candidate to image the localization of this allergen in vivo: (a) upon conjugation to the iron oxide nanoparticles, the allergen retains its ability to interact with IgE antibodies; (b) the magnetic properties of the iron oxide core of this bioconjugate are suitable for MR imaging; and (c) Alexa647 fluorophore retains its emission properties once attached to the iron oxide nanoparticles, yielding a dual modality MRI-optical probe.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Biomedical Applications; Magnetic Nanoparticles; Functionalization; Iron Oxide Nanoparticles; Mri; Allergen; Optical Probe; BIOMEDICAL APPLICATIONS; MAGNETIC NANOPARTICLES; FUNCTIONALIZATION
ISSN (print) / ISBN
1555-4309
e-ISSN
1555-4317
Zeitschrift
Contrast Media & Molecular Imaging
Quellenangaben
Band: 7,
Heft: 4,
Seiten: 435-439
Verlag
Wiley
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute for Allergy Research (IAF)