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Altun, I. ; Vo, K.H.D. ; Walia, S.R. ; Yan, X. ; Singh, I. ; Karlina, R. ; Miok, V. ; Kang, L. ; Reichenbach, V.K. ; Israel, A. ; Lutter, D. ; Perocchi, F. ; Ussar, S.

Igf2 regulates early postnatal DPP4+ preadipocyte pool expansion.

Genes Dev. 39, 1414-1425 (2025)
Verlagsversion Forschungsdaten DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Adipose tissue is rapidly expanding early in life. Elucidating the queues facilitating this process will advance our understanding of metabolically healthy obesity. Using single-cell RNA sequencing, we identified compositional differences of prewean and adult murine subcutaneous adipose tissue. We identified a dipeptidyl peptidase-4 (Dpp4)-positive precursor population residing in the reticular interstitium of subcutaneous adipose expressing insulin growth factor 2 (Igf2) in prewean mice. We show that IGF2 drives proliferation rather than differentiation in these cells. Moreover, loss of Igf2 in Dpp4 + progenitor cells promotes adipogenesis. Our findings unravel the temporally restricted expression of Igf2 to promote preadipocyte expansion.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Adipose Tissue Development ; Dpp4+ ; Igf2 ; Hyperplasia ; Preadipocyte ; Progenitor Cells; Growth-factor-ii; Adipose-tissue; Adipogenesis; Receptor; Fetal
ISSN (print) / ISBN 0890-9369
e-ISSN 1549-5477
Zeitschrift Genes and Development
Quellenangaben Band: 39, Heft: 23-24, Seiten: 1414-1425 Artikelnummer: , Supplement: ,
Verlag Cold Spring Harbor Laboratory Press
Verlagsort 1 Bungtown Rd, Cold Spring Harbor, Ny 11724 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Adipocytes & Metabolism (ADM)
Institute of Diabetes and Obesity (IDO)
Förderungen Initiative and Network Fund of the Helmholtz Association
Munich Center for Systems Neurology