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Freuer, D.* ; Linseisen, J.* ; Schmitz, T.* ; Thorand, B. ; Peters, A. ; Petrera, A. ; Heier, M. ; Meisinger, C.*

Pleiotropic effects between statin intake and inflammation parameters in two distinct population-based studies.

Commun. Med. 5:387 (2025)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
BACKGROUND: Besides their lipid lowering effects, statins exhibit numerous beneficial and adverse effects (so called pleiotropic effects). A major pleiotropic effect of statins is their anti-inflammatory properties, but the impact on a wide range of inflammation-related proteins involved in specific metabolic pathways remains inconclusive. Therefore, in this study we examined the association between statin use and numerous circulating levels of inflammation-related proteins using data from two independent population-based studies. METHODS: The association between statin intake and up to 90 inflammation-related proteins (Olink Proteomics) were investigated in 803 and 1008 participants of the KORA-Fit and KORA-Age1 studies, respectively (overall age range: 53-93 years, 52% women). Association-specific multivariable parametric as well as non-parametric regression models were performed to obtain robust estimates. Confounding factors were selected using directed acyclic graphs and the potential effect of unmeasured confounding was assessed. RESULTS: After adjustment for multiple testing, 3 and 8 associations remain in the KORA-Fit and KORA-Age1 studies, respectively. The strongest evidence (in terms of effect size, replication, and robustness) is found for the positive associations with the inflammation-related proteins TRANS ( β F i t  = 0.21; 95% CI = [0.08; 0.33]; P F D R  = 0.035, β A g e 1  = 0.13; 95% CI = [0.05; 0.21]; P F D R  = 0.019) and TRAIL ( β F i t  = 0.09; 95% CI = [0.03; 0.15]; P F D R  = 0.045, β A g e 1  = 0.09; 95% CI = [0.05; 0.13]; P F D R  =  5 ⋅ 10 - 4 ) and the negative association with SCF ( β F i t  = _0.11; 95% CI = [-0.19; -0.03]; P F D R  = 0.121, β A g e 1  = -0.11; 95% CI = [-0.17; -0.06]; P F D R  = 0.003). Further associations with NT-3, MMP-10, uPA, and CD244 found in one of the studies are consistent with the point estimates of the other study. CONCLUSIONS: The present study identifies associations between statin intake and inflammation-related proteins pointing to certain metabolic pathways. The results could contribute to a better understanding of the mechanisms underlying the pleiotropic effect of statins.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Stem-cell Factor; Apoptosis-inducing Ligand; Kappa-b Ligand; Cardiovascular-disease; Receptor Activator; Health; Outcomes; Biology; System; Member
ISSN (print) / ISBN 2730-664X
e-ISSN 2730-664X
Zeitschrift Communications Medicine
Quellenangaben Band: 5, Heft: 1, Seiten: , Artikelnummer: 387 Supplement: ,
Verlag Springer
Verlagsort Campus, 4 Crinan St, London, N1 9xw, England
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
CF Metabolomics & Proteomics (CF-MPC)
Förderungen German Federal Ministry of Education and Research (BMBF)
State of Bavaria
Helmholtz Zentrum Muenchen-German Research Center for Environmental Health - German Federal Ministry of Education and Research (BMBF)