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Hesse, S.* ; Rullmann, M.* ; Günnewig, T.* ; Schweickert de Palma, E.* ; Burmeister, L.* ; van Grinsven, M.* ; Zientek, F.* ; Luthardt, J.* ; Hankir, M.K.* ; Meyer, P.M.* ; Becker, G.A.* ; Patt, M.* ; Brust, P.* ; Pleger, B.* ; Stumvoll, M.* ; Hilbert, A.* ; Blüher, M. ; Sabri, O.*

Cholinergic network modulation in disinhibited eating behavior.

Comm. Biol. 8:1347 (2025)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Cholinergic modulation of brain reward circuitry appears to play a crucial role in information processing about salience as a key biological mechanism in obesity. However, changes in acetylcholine transmission leading to abnormal eating behavior have not been demonstrated in vivo in human obesity. Using simultaneous positron emission tomography and functional magnetic resonance imaging, we found an increased α4β2* nicotinic acetylcholine receptors (nAChR) availability in response to visually salient food cues in twenty individuals with obesity, particularly in those with high disinhibited eating behavior, whereas there was no change in sixteen volunteers served as normal weight control. This increase was accompanied by a shift from dorsal attention network activation in normal-weight controls to salience network activation in individuals with obesity indicating fundamental differences in sensory cue detection. These data should encourage further investigations into α4β2* nAChR in obesity, particularly with regard to treatment with nicotinic receptor agonists for weight loss targeting hedonic overeating.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Food-cue Reactivity; Acetylcholine-receptors; Nicotinic Receptors; Reward; Addiction; Obesity; Mechanisms; Pathways; Smoking
Sprache englisch
Veröffentlichungsjahr 2025
HGF-Berichtsjahr 2025
ISSN (print) / ISBN 2399-3642
e-ISSN 2399-3642
Zeitschrift Communications Biology
Quellenangaben Band: 8, Heft: 1, Seiten: , Artikelnummer: 1347 Supplement: ,
Verlag Springer
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
POF Topic(s) 30201 - Metabolic Health
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-506501-001
Förderungen Projekt DEAL
Leipzig University
Federal Ministry of Education and Research (BMBF), Germany
DOI 10.1038/s42003-025-08716-2
WOS ID 001572833600001
Scopus ID 105016585822
PubMed ID 40962900
Erfassungsdatum 2025-11-04
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