PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Schultz, J.* ; Patel, P.A.* ; Aires, R.* ; Wissing, L.* ; Glatte, P.* ; Seifert, M.* ; Gentzel, M.* ; Fitze, G.* ; Doyle, A.M.* ; Sandoval-Guzmán, T.

Human fingertip regeneration follows clinical phases with distinct proteomic signatures.

npj Reg. Med. 10:51 (2025)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Distal injuries in human fingertips can regenerate almost fully, yet the process of human fingertip regeneration has hardly been characterized on a cellular and molecular level. A silicone finger cap, comprising a puncturable reservoir, was used to treat 22 human fingertip amputations. In all patients, subcutaneous tissue, nailbed and skin regenerated with excellent outcomes. Through the clinical assessment of the wounds, the regenerative process was divided into four distinct phases. Proteomic data from wound fluid samples collected at regular intervals, confirmed robust and unbiasedly distinct proteomic signatures, characteristic processes, and active regulatory networks in each phase. Moreover, this human dataset provides important insights, showing clear divergences from findings in regenerative animal models. The longitudinal and comprehensive analysis presented here unveils the complex orchestration of four clinically and proteomically-distinct phases of human fingertip regeneration. Further analyses of this proteomic data will allow for the identification of candidates orchestrating human fingertip regeneration and serving as a framework for comparative and regenerative medicine studies. This clinical trial was registered at ClinicalTrials.gov Identifier: NCT03089060 on March 17, 2017.
Impact Factor
Scopus SNIP
Altmetric
6.500
0.000
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Conservative Management; Limb Regeneration; Mass-spectrometry; Tip Injuries; Amputation; Expression; Reconstruction; S100a8/a9; Proteins; Platform
Sprache englisch
Veröffentlichungsjahr 2025
HGF-Berichtsjahr 2025
ISSN (print) / ISBN 2057-3995
e-ISSN 2057-3995
Zeitschrift npj Regenerative Medicine
Quellenangaben Band: 10, Heft: 1, Seiten: , Artikelnummer: 51 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Pancreatic Islet Research (IPI)
POF Topic(s) 90000 - German Center for Diabetes Research
PSP-Element(e) A-502600-001
Förderungen Freestate of Saxony under the Excellence Strategy of the Federal Government and the Lnder
Medical Faculty C. G. Carus, Technical University Dresden
Deutsche Forschungsgemeinschaft, Germany
Federal Ministry of Education and Research (BMBF)
European Regional Development Fund (ERDF/EFRE)
Deutsche Forschungsgemeinschaft
Alexander von Humboldt-Stiftung
German Federal Government
DOI 10.1038/s41536-025-00441-y
WOS ID 001608567200001
Scopus ID 105020935172
PubMed ID 41193504
Erfassungsdatum 2025-11-07
[➜Korrektur melden]