Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Reawakening cAMP signalling in cancer cachexia.
Nat. Metab., DOI: 10.1038/s42255-025-01417-4 (2025)
The question of why muscle wasting persists in cancer cachexia despite adequate nutrition has long since intrigued researchers. Here, the authors identify PDE4D-mediated suppression of cAMP–PKA–CREB1 signalling as a driver of mitochondrial dysfunction and show that PDE4D inhibition preserves muscle bioenergetics and mass in cancer cachexia.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Fachkommentar, Meinungsartikel
ISSN (print) / ISBN
2522-5812
e-ISSN
2522-5812
Zeitschrift
Nature metabolism
Verlag
Springer
Verlagsort
London
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Diabetes and Cancer (IDC)
Förderungen
European Research Council (ERC)
German Research Foundation
European Research Council (ERC) under the European Union
German Research Foundation
European Research Council (ERC) under the European Union